(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐 CAS#: 1222781-70-5

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(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐

生物活性体外研究靶点 用途与合成方法 MSDS (4-甲氧基苄基)(1-萘基甲基)胺盐酸盐价格(试剂级) 上下游产品信息

中文名称	(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐
中文同义词	ML133 HCL (4-甲氧基苄基)(1-萘基甲基)胺盐酸盐;N-[(4-甲氧基苯基)甲基]-1-萘甲胺盐酸盐;(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐;ML133盐酸盐;N-(4-甲氧基苄基)-1-(萘-1-基)甲胺盐酸盐;中文名:?(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐英文名:?N-(4-METHOXYBENZYL)-1-(NAPHTHALEN-1-YL)METHANAMINE HYDROCHLORIDECAS号:1222781-70-5
英文名称	ML 133 Hydrochloride
英文同义词	(4-Methoxybenzyl)(1-naphthylMethyl)aMine Hydrochloride;ML 133 Hydrochloride;1-(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine hydrochloride;CID 781301 hydrochloride;N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine hydrochloride (1:1);ML133 HCl;1-Naphthalenemethanamine, N-[(4-methoxyphenyl)methyl]-, hydrochloride (1:1);N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride
CAS号	1222781-70-5
分子式	C19H20ClNO
分子量	313.83
EINECS号
相关类别	膜转运/离子通道;离子通道;膜转运;小分子抑制剂，天然产物;Inhibitors;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol文件	1222781-70-5.mol
结构式

(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐 性质

(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐 用途与合成方法

生物活性

ML133 HCl是一种选择性钾离子通道抑制剂，作用于K_ir2.1， IC50为1.8 μM (pH 7.4)和290 nM (pH 8.5)，对K_ir1.1没有作用效果，对K_ir4.1和K_ir7.1具有微弱的作用活性。

体外研究

The ratio of total concentration of extracellular ML133 versus intracellular ML133 is 1:0.13 at pH 6.5, 1:9.09 at pH 8.5. ML133 is clean against 3A4 and 2C9 (IC50 >30 μM), displays moderate inhibition of 1A2 (IC50 = 3.3 μM) but proves to be a potent inhibitor of 2D6 (IC50 = 0.13 μM) in CYP450 assay. ML133 is highly protein bound (>99%) in both human and rat and also displays high intrinsic clearance in both species. ML133 (10 μM) is not displaced by K⁺ influx from the wild-type K_ir2.1 in HEK 293 cells. M1 and/or M2 transmembrane domains contain the critical molecular determinant for ML133 inhibition of K_ir2.1, especially D172 and I176.

靶点

IC50: 1.8 μM (K     _ir    2 at pH 7.4), 290 nM (K     _ir    2 at pH 8.5).

安全信息

MSDS信息

(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐 价格(试剂级)

(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐 上下游产品信息