VAS2870 CAS#: 722456-31-7

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VAS2870

简介生物活性靶点体外研究 用途与合成方法 MSDS VAS2870价格(试剂级) 上下游产品信息

中文名称	VAS2870
中文同义词	化合物VAS2870;2-((3-苄基-3H- [1,2,3]三唑并[4,5-D]嘧啶-7-基)硫代)苯并[D]恶唑;VAS 2870,NADPH氧化酶抑制剂;2-((3-苄基-3H- [1,2,3]三唑并[4,5-D]嘧啶-7-基)硫基)苯并[D]恶唑
英文名称	1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide
英文同义词	1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide;7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine;7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine;VAS 2870;VAS2870;VAS-2870;NOX Inhibitor III, VAS2870;2-(3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ylthio)benzo[d]oxazole
CAS号	722456-31-7
分子式	C18H12N6OS
分子量	360.39
EINECS号
相关类别
Mol文件	722456-31-7.mol
结构式

VAS2870 性质

VAS2870 用途与合成方法

简介

VAS-2870 (722456-31-7) 是一种 NAD(P)H 氧化酶 (Nox) 抑制剂。其可抑制 HL-60 细胞中 由PMA 诱导的氧化反应(IC50=2 μM)，可 增强 TGF-β 诱导的肝肿瘤细胞的凋亡。

生物活性

VAS2870是一种泛NADPH oxidase(NOX)抑制剂。

靶点

体外研究

VAS2870 is effective to suppress PDGF-BB-dependent activation of NADPH oxidase and subsequent production of intracellular ROS. Furthermore, VAS2870 suppresses PDGF-BB-dependent chemotaxis, but not DNA synthesis. Preincubation with VAS2870 (10 and 20 μM) completely abolishes PDGF-mediated NADPH oxidase activation and ROS production. Preincubation with VAS2870 (0.1-20 μM) does not affect PDGF-induced cell cycle progression. However, it abolishes PDGF-dependent chemotaxis of VSMC in a concentration-dependent manner (100% inhibition at 10 μM). VAS2870 inhibits dose-dependently autocrine increase of cell number in FaO rat hepatoma cells, and almost completely blocked ROS production and thymidine incorporation when used at 25 mM. VAS2870 blocks serum-dependent cell growth of FaO rat hepatoma cells. VAS2870 inhibits proliferation of different human hepatocellular carcinoma (HCC) cell lines. VAS2870 pretreatment enhances TGF-b-mediated apoptosis of FaO rat hepatoma cells.

安全信息

MSDS信息

VAS2870 价格(试剂级)

VAS2870 上下游产品信息