CPD1578 CAS#: 125079-83-6

微信扫码

CPD1578

生物活性靶点体外研究 用途与合成方法 MSDS CPD1578价格(试剂级) 上下游产品信息

中文名称	CPD1578
中文同义词	7-(间甲苯基)吡唑并[1,5-A]嘧啶-3-甲酰胺;化合物CU-CPT-8M
英文名称	CU-CPT-8m
英文同义词	CPD1578;CU-CPT-8m;cas 125079-83-6;CU-CPT-8M;CAS 125079-83-6 ;TLR8 INHIBITOR;TLR8-specific antagonist;7-(m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 7-(3-methylphenyl)-;CU CPT 8m,inhibit,Toll-like Receptor (TLR),CUCPT8m,Inhibitor
CAS号	125079-83-6
分子式	C14H12N4O
分子量	252.27
EINECS号
相关类别
Mol文件	125079-83-6.mol
结构式

CPD1578 性质

CPD1578 用途与合成方法

生物活性

CU-CPT-8m 是 TLR8 的特异性拮抗剂，其 IC50 值为 67 nM。

靶点

体外研究

CU-CPT-8m is a specific     TLR8    antagonist, with an     IC   ₅₀      of 67±10 nM and negligible cytotoxicity. The K     _d    value of CU-CPT-8m is determined to be 220 nM. CU-CPT-8m only reduces the proinflammatory response in the TLR8-overexpressing cells strongly supports that CU-CPT-8m directly recognizes TLR8 in cells. It is particularly notable that TLR7 signaling is not affected at concentrations up to 75 μM. TLR7 and TLR8 are closely related and share many common ligands. Treatment of 1 μM CU-CPT-8m completely abolishes the elevation of TNF-α and IL-8 mRNA levels induced by R848. CU-CPT-8m inhibits R848-induced TNF-α production in the differentiated THP-1 monocytes cells in a dose-dependent manner with an IC     ₅₀    of 90±10 nM, which is in good agreement with its IC     ₅₀    value determined in HEK-Blue TLR8 cells.

安全信息

MSDS信息

CPD1578 价格(试剂级)

CPD1578 上下游产品信息