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| 中文名: | PD153035 HCl;6,7-二甲氧基-4-[N-(3-溴苯基)氨基]喹唑啉盐酸盐 |
| 中文别名: | 4-[(3-溴苯基)氨基]-6,7-二甲氧基喹唑啉盐酸盐盐; |
| 英文名称： | PD153035 hydrochloride |
| 英文别名： | 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochloride;AG 1517;PD 153035;SU 5271;ZM 252868 |
| CAS No.: | 183322-45-4 |
| 分子式: | C16H15BrClN3O2 |
| 分子量: | 396.67 |
| 性状: | 属性溶解性Soluble in DMSO (10 mM) with gentle warming, water (<1 mg/mL at 25 °C), and ethanol ( <1 mg/mL at 25 °C).存贮条件储存温度-20°C描述产品介绍PD153035 HCl是一种有效的，特异性的EGFR抑制剂，Ki和IC50分别为5.2 pM和29 pM；对PGDFR， FGFR， CSF-1，InsR和Src几乎无作用。用途A potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase生化机理PD 153035 Hydrochloride is an extremely potent inhibitor of EGFR (epidermal growth factor receptor) tyrosine kinase (IC50 = 25 pM). Only inhibits other purified tyrosine kinases at micromolar or higher concentrations. |
| 储存: | 储存温度-20°C |
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| 用途: | PD153035 hydrochloride is a hydrochloride acid salt form of PD153035 which is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM.PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells, PD153035 not only blocks cell growth via inhibition of EGFR, but also upregulates the expression of the tumor suppressor retinoic acid receptor-beta 2 (RAR-beta2). [1][2] |
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