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| 中文名: | PF-04217903;2-(4-(1-(喹啉-6-基甲基)-1H-[1,2,3]三唑并[4,5-b]吡嗪-6-基)-1H-吡唑-1-基)乙醇 |
| 中文别名: | PF 04217903; 2-[4-[1-(喹啉-6-甲基)-1H-[1,2,3]三唑并[4,5-b]吡嗪-6-基]-1H-吡唑-1-基]乙醇 |
| 英文名称： | PF-04217903 |
| 英文别名： | PF04217903;PF 04217903;2-{4-[1-(6-Quinolinylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazol-1-yl}ethanol |
| CAS No.: | 956905-27-4 |
| 分子式: | C19H16N8O |
| 分子量: | 372.38 |
| 性状: | 属性溶解性Soluble in DMSO (5 mg/mL at 25 °C), water (<1 mg/mL at 25 °C), and ethanol (<1 mg/mL at 25 °C).存贮条件储存温度-20°C描述产品介绍PF-04217903是一种选择性的，ATP竞争性c-Met抑制剂，IC50为4.8 nM，对致癌基因突变型敏感(对Y1230C突变型没有活性)。用途A selective ATP-competitive Met inhibitor.生化机理PF-04217903 is a selective ATP-competitive Met inhibitor (IC50 = 4.8 nM). |
| 储存: | 储存温度-20°C |
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| 用途: | PF-04217903 is an orally bioavailabe, small-molecule MET tyrosine kinase inhibitor with potential antineoplastic activity. [1] |
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