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| 中文名: | SRT1720;SRT1720 |
| 中文别名: | SRT-1720;SRT 1720; N-[2-[3-(1-哌嗪甲基)咪唑并[2,1-b]噻唑-6-基]苯基]-2-喹喔啉甲酰胺盐酸盐 |
| 英文名称： | SRT1720 |
| 英文别名： | SRT-1720;SRT 1720;SRT 1720 Hydrochloride;N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide hydrochloride |
| CAS No.: | 1001645-58-4 |
| 分子式: | C25H23N7OS.HCl |
| 分子量: | 506.02 |
| 性状: | 属性溶解性DMSO 38 mg/mLWater<1 mg/mLEthanol<1 mg/mL存贮条件储存温度-20°C描述产品介绍SRT1720是一种选择性的SIRT1激活剂，EC50为0.16 μM，比作用于SIRT2和SIRT3效果弱230倍以上。用途A selective SIRT1 activator生化机理SRT1720 is an NAD-dependent deacetylase sirtuin-1 (SIRT1) activator (EC50 = 0.16 μM), highly selective for SIRT1 over SIRT2 or SIRT3. Studies in yeast suggest that sirtuins may be involved in epigentic gene silencing and deactylation of proteins that regulate the cell cycle. |
| 储存: | 储存温度-20°C |
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| 用途: | SRT1720 is a selective activator of human SIRT1 (EC1.5 = 0.16 μM and maximum activation = 781%) versus the closest sirtuin homologues, SIRT2 and SIRT3，(SIRT2: EC1.5 = 37 μM；SIRT3: EC1.5 > 300 μM). This agent binds to the SIRT1 enzyme-peptide substrate complex at an allosteric site amino-terminal to the catalytic domain and lower the Michaelis constant for acetylated substrates. [1] |
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