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| 中文名: | 5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮;AS-252424 |
| 中文别名: | AS 252424; 5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮 |
| 英文名称： | AS-252424 |
| 英文别名： | 5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione;AS 252424 |
| CAS No.: | 900515-16-4 |
| 分子式: | C14H8FNO4S |
| 分子量: | 305.28 |
| 性状: | 属性溶解性Soluble in DMSO (~20 mg/ml), 100% ethanol (10 mg/ml), DMF (~20 mg/ml), and 1:1 solution of DMSO:PBS, pH 7.4 (0.5 mg/ml).存贮条件储存温度 2-8°C描述产品介绍AS-252424是一种新型，有效的PI3Kγ抑制剂，IC50为30 nM，作用于PI3Kγ比作用于PI3Kα选择性高30倍，对PI3Kδ/β具有低的抑制活性。用途A selective PI 3-kinase p110γ inhibitor.生化机理AS-252424 is a potent and selective PI 3-kinase p110γ inhibitor (IC50 = 33 nM) shown to be selective for class IB PI 3-kinase-mediated cellular effects. AS-252424 also prevents C5a-mediated phosphorylation of Akt in RAW 264.7 macrophages with an IC50 of 0.23 μM. AS-252424 is an inhibitor of Casein Kinase and PI 3-kinase p110 α. |
| 储存: | 储存温度 2-8°C |
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| 用途: | A selective PI 3-kinase p110γ inhibitor. |
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