链球菌溶素O CAS#: 98072-47-0

链球菌溶素O

分类生物活性体外研究 用途与合成方法 MSDS 链球菌溶素O价格(试剂级) 上下游产品信息 专题

中文名称	链球菌溶素O
中文同义词	链球菌溶素O;链球菌溶血素O;链球菌;溶血素 O;ATCC 15300 链球菌;化合物 T19565;链球菌溶血素O 来源于化脓链球菌;溶血素O抗原SLO
英文名称	STREPTOLYSIN O
英文同义词	STREPTOLYSIN O;STREPTOLYSIN O REAGENT;Hemolysins O, Streptococcus group A;STREPTOLYSIN O GAMMA-IRRADIATED;STREPTOLYSIN O FROM STREPTOCOCCUS*PYOGEN ES;Einecs 308-500-3;Native Streptococcus pyogenes Streptolysin O;Streptococcus sp.
CAS号	98072-47-0
分子式	NULL
分子量	0
EINECS号	308-500-3
相关类别	酶制剂;菌种;Antibiotics  N-SSignal  Transduction  Research  Tools;EnzymesApplication  Index;Lysing  Enzymes  and  Protoplast  PreparationEnzymes,  Inhibitors,  and  Substrates;Antibiotics;Antibiotics  A  to;Cell  Dissociation  and  Cell  Lysis;BacteriaSignal  Transduction  Research  Tools;Cell  Lysis  Reagents;Cell  Signaling  and  Neuroscience;Enzymatic  Cell  Lysis  and  Protoplast  Preparation;EnzymesEnzymes,  Inhibitors,  and  Substrates;Mammalian;Toxins  and  Venoms
Mol文件	Mol File
结构式

链球菌溶素O 性质

链球菌溶素O 用途与合成方法

分类

按对绵羊红细胞溶血能力可分为：①甲型(a)溶血性链球菌，又称草绿色链球菌，是人类呼吸道及肠道的正常寄居菌，致病力低。②乙型(β)溶血性链球菌，又称溶血性链球菌，致病力强，可引起人或动物多种疾病。③丙型链球菌，又称非溶血性链球菌，一般无致病性，常存在于乳品及粪便中。其中研究最多的为乙型(β)溶血性链球菌。

生物活性

Streptolysin O，A组链球菌毒素，是一个氧不稳定原型胆固醇结合细菌外毒素。Streptolysin O 导致细胞裂解和心脏毒性。Streptolysin O 用于细胞膜的可控渗透性。Streptolysin O 以两种形式存在，即还原活性状态和氧化可逆不活动状态。

体外研究

Streptolysin O is a labile toxin, and, with time, activity is irreversibly lost. The rate of activity loss is slowed by incubation with 0.1 M 2-mercaptoethanol or 0.01 M ethylenediaminetetraacetic acid (EDTA).  
 Streptolysin O, belongs to the group of thiol-activated toxins, is a secreted virulence factor of GAS that induces apoptosis in neutrophils and macrophages at later time points (~4 h). Streptolysin O induces eukaryotic cell lysis in a cholesterol-dependent manner, is highly upregulated in the GAS M1T1 clone during bloodstream dissemination. Streptolysin O is known to promote Group A Streptococcus (GAS) resistance to phagocytic clearance by neutrophils, a critical first element of host defense against invasive bacterial infection.

安全信息

MSDS信息

链球菌溶素O 价格(试剂级)

链球菌溶素O 上下游产品信息