Seratrodast 50 mg_行业前沿_产品

同义词： AA 2414; 7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid; Thromboxane receptor ligand

应用； A potent and selective thromboxane A2 receptor (TP) antagonist

CAS号码: 112665-43-7

纯度: ≥99%

分子量: 354.44

分子式: C₂₂H₂₆O₄

* 参考分析证明大量特定数据 (包括水含量).

介绍技术信息安全信息安全技术说明书和分析证明书

Seratrodast, also known as AA-2414, is a potent and selective antagonist of the TXA2R (thromboxane A₂ receptor). Seratrodast is described to produce antioxidant effects, and is demonstrated to inhibit peroxide-induced vasoconstriction in human placenta. Additionally, it inhibit bronchoconstriction in guinea pigs in response to leukotriene D4, U-46619, and platelet activating factor.

参考文献

1. Ashida, Y., et al. 1989. Prostaglandins. 38: 91-112. PMID: 2748922
2. Kurokawa, T., et al. 1994. Biol. Pharm. Bull. 17: 383-385. PMID: 8019502
3. Hussein, Z., et al. 1994. Clin. Pharmacol. Ther. 55: 441-450. PMID: 8162671
4. Walsh, S.W., et al. 1999. J. Pharmacol. Exp. Ther. 290: 220-226. PMID: 10381779
5. Cui, S., et al. 2007. Eur. J. Pharmacol. 576: 99-106. PMID: 17706964

物理状态 :

Solid

溶解度 :

Soluble in DMSO (12 mg/ml), ethanol (10 mg/ml), methanol, and NaOH.

保存 :

Store at room temperature

熔点 :

127-129° C

沸点 :

522.34° C at 760 mmHg

密度 :

1.14 g/cm ³

折射率 :

n ²⁰ _D 1.56

IC50 :

Thromboxane A2 receptor: IC ₅₀ = 7.4 nM (human); Oryctolagus cuniculus: IC ₅₀ = 100 nM; Cavia porcellus: IC ₅₀ = 350 nM

pK值 :

pK _a: 4.76

仅供科研使用。不可用于诊断或治疗。

RTECS :

DA1600050

PubChem CID :

2449

默克索引 :

14: 8459

SMILES :

CC1=C(C(=O)C(=C(C1=O)C)C(CCCCCC(=O)O)C2=CC=CC=C2)C