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| Description | |
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| Overview | Native C-reactive protein highly purified from human serum. CRP is a major acute-phase plasma protein that is dramatically elevated in patients with acute-phase conditions. Composed of five identical noncovalently linked subunits. Exhibits Ca2+-dependent binding to a variety of substrates. Important in diagnosis of rheumatoid arthritis. Suitable for immunological studies. In purified states and in plasma the monomeric form (M.W. ~21 kDa) aggregates as a cyclic pentamer. Intended for use as a calibration standard for assays of CRP, for structural and functional studies, and as an antigen for production of antisera. Calibrated by electroimmunoassay against WHO reference standard or equivalent. |
| M.W. 23,000 (monomer); 115,000 (pentamer). | |
| No reaction in ODD and Laurell electroimmunoassay against polyvalent antiserum to normal human serum, antiserum to pooled effusion fluids and monospecific antiserum to human IgG. | |
| Catalogue Number | 236603 |
| Brand Family | Calbiochem® |
| Synonyms | CRP |
| References | |
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| References | Paffen, E., et al. 2004. Arterioscler. Thromb. Vasc. Biol. 24, 975. |
| Product Information | |
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| CAS number | 9007-41-4 |
| Form | Liquid |
| Formulation | In 140 mM NaCl, 10 mM Tris, 2 mM CaCl₂, 0.1% NaN₃, pH 8.0. |
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| Biological Information | |
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| Purity | ≥99% by SDS-PAGE |
| Source | Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV. |
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| Ship Code | Dry Ice Only |
| Toxicity | Standard Handling |
| Storage | ≤ -70°C |
| Avoid freeze/thaw | Avoid freeze/thaw |
| Do not freeze | Ok to freeze |
| Special Instructions | Following initial thaw, aliquot and freeze (-70°C). |
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