产品编号:

200-06RC

别名:

soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126

描述:

IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6R伪 and gp130.  While the IL-6R伪 chain is the binding component specific to IL-6, the gp130 chain only transmits signals of IL-6 when bound to IL-6R伪.  The gp130 can also transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits.  The low-affinity binding site for IL-6 is composed of IL-6R伪 alone.  IL-6R伪 is expressed in a wide range of cells, including T cells, fibroblasts and macrophages.  Soluble IL-6R伪, which consists of only the extracellular domain of the IL-6R伪 chain, acts as an agonist of IL-6 activity at low concentrations. PeproTech's CHO cell-derived Recombinant Human sIL-6 Receptor 伪 is a 37.9 kDa glycoprotein corresponding to 339 amino acid residues of the extracellular domain of IL-6R伪. As a result of glycosylation, Recombinant Human sIL-6 Receptor 伪 migrates with an apparent molecular mass of approximately 57-70 kDa by SDS-PAGE gel, under reducing conditions.

氨基酸序列:

LAPRRCPAQE VARGVLTSLP GDSVTLTCPG VEPEDNATVH WVLRKPAAGS HPSRWAGMGR RLLLRSVQLH DSGNYSCYRA GRPAGTVHLL VDVPPEEPQL SCFRKSPLSN VVCEWGPRST PSLTTKAVLL VRKFQNSPAE DFQEPCQYSQ ESQKFSCQLA VPEGDSSFYI VSMCVASSVG SKFSKTQTFQ GCGILQPDPP ANITVTAVAR NPRWLSVTWQ DPHSWNSSFY RLRFELRYRA ERSKTFTTWM VKDLQHHCVI HDAWSGLRHV VQLRAQEEFG QGEWSEWSPE AMGTPWTESR SPPAENEVST PMQALTTNKD DDNILFRDSA NATSLPVQD

来源:

CHO cells

纯度:

Greater than 95% by SDS-PAGE gel and HPLC analyses.

生物活性:

Determined by its ability to intensify the IL-6 induced growth inhibition of mouse M1 cells.  The expected ED₅₀ is 鈮?5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6.

原产国:

USA