产品编号:

450-16

别名:

MK, NEGF-2

描述:

Midkine (MK) and the functionally-related protein pleiotrophin are heparin-binding neurotrophic factors that signal through the same receptor, known as anaplastic lymphoma kinase (ALK).  MK plays an important regulatory role in epithelial-mesenchymal interactions during fetal development and in postnatal lung development.  MK chemoattracts embryonic neurons, neutrophils and macrophages, and exerts angiogenic, growth and survival activities during tumorigenesis.  Recombinant Human Midkine is a 13.4 kDa protein containing 123 amino acid residues including five intra-molecular disulfide bonds.

氨基酸序列:

VAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETI RVTKPCTPKT KAKAKAKKGK GKD

来源:

E.coli

纯度:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

生物活性:

Determined by its ability to chemoattract human neutrophils using a concentration range of 0.1-10.0 ng/ml.

交叉反应:

Bacteria, Mouse, Pig, Shark, Squid, Hagfish, Human

原产国:

USA