详细说明
应用; The enzymatic component of the holotoxin
分子量: 28000
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* 参考分析证明 大量特定数据 (包括水 含量).
介绍 技术信息 安全信息 安全技术说明书和分析证明书
Pertussis Toxin, A Protomer is the enzymatic component of the holotoxin. It has both NAD-glycohydrolase and ADP-ribosyltransferase activities. Pertussis Toxin, A Protomer inhibits neutrophil-mediated inflammation through its ADP-ribosylation activity, however, it is unable to infiltrate cells in the absence of the B oligomer.
参考文献
1. Kaslow, H R., et al., 1989. Alkylation of cysteine 41, but not cysteine 200, decreases the ADP-ribosyltransferase activity of the S1 subunit of pertussis toxin. The Journal of biological chemistry. 264(11): 6386-90. PMID: 2703495
2. Gill, D M., et al., 1988. ADP-ribosylation of membrane proteins by bacterial toxins in the presence of NAD glycohydrolase. Biochimica et biophysica acta. 954(1): 65-72. PMID: 2833927
3. Burns, D L., et al., 1986. Adenine nucleotides promote dissociation of pertussis toxin subunits. The Journal of biological chemistry. 261(9): 4324-7. PMID: 3005329
4. Tamura, M., et al., 1982. Subunit structure of islet-activating protein, pertussis toxin, in conformity with the A-B model. Biochemistry. 21(22): 5516-22. PMID: 6293544
5. Moss, J., et al., 1983. Activation by thiol of the latent NAD glycohydrolase and ADP-ribosyltransferase activities of Bordetella pertussis toxin (islet-activating protein). The Journal of biological chemistry. 258(19): 11879-82. PMID: 6311827
6. Brito, G A., et al., 1997. Role of pertussis toxin A subunit in neutrophil migration and vascular permeability. Infection and immunity. 65(3): 1114-8. PMID: 9038326
物理状态 :
Solid
来源于 :
<i>Bordetella pertussis</i>
溶解度 :
Soluble in reconstitute with 500 µl sterile, and high ionic buffer.
保存 :
Store at 4° C
仅供科研使用。不可用于诊断或治疗。
运输 :
UN 3462, Class 6.1, Packing group II