Background: Hrk

HRK (harakiri) is a 10 kDa pro-apoptotic member of the Bcl-2 family of apoptosis regulatory proteins. Hrk lacks significant homology to other Bcl-2 family members except for an 8-amino acid region that is similar to the BH3 domain of Bik (Bcl-2-interacting Killer). Hrk physically interacts with Bcl-2 and Bcl-xL, but not with the pro-apoptotic Bax, BAK, or Bcl-xS. Hrk regulates apoptosis by interacting selectively with survival-promoting Bcl-2 and Bcl-xL to induce cell death.

• Long Name:

  Harakiri

• Entrez Gene IDs:

  8739 (Human)

• Alternate Names:

  activator of apoptosis harakiri; activator of apoptosis Hrk; BCL2-interacting protein; BH3-interacting domain-containing protein 3; BID3; death protein 5; DP5; HARAKIRI; harakiri, BCL2 interacting protein (contains only BH3 domain); harakiri, BCL2-interacting protein (contains only BH3 domain); Hrk; Neuronal death protein DP5