Recombinant Human His6-USP28 Protein, CF 100 UG

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Recombinant Human His6-USP28 Protein, CF 100 UG信息二维码

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产品介绍

    基本参数

    详细说明

    • Purity

      >90%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain

    • Activity

      Recombinant Human USP28 is a Ubiquitin-specific deconjugating enzyme. Reaction conditions will need to be optimized for each specific application. We recommend an initial Recombinant Human USP28 concentration of 10-500 nM.  

    • Source

      Spodoptera frugiperda,     Sf 21 (baculovirus)-derived Contains a C-terminal 6-His tag

    • Accession #

    • Predicted Molecular Mass

      123 kDa

    E-570

     

    Formulation      

    X mg/ml (X μM) in 50 mM Hepes pH 7.5, 100 mM NaCl, 1 mM TCEP





    Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.


    Stability & Storage:       Use a manual defrost freezer and avoid repeated freeze-thaw cycles.      

    • 12 months from date of receipt, -70 °C as supplied.

    • 3 months, -70 °C under sterile conditions after opening.


    Background: USP28

    USP28 is a deubiquitinating enzyme of the C19 peptidase family that regulates MYC stability and DNA damage response checkpoints. USP28 regulates DNA repair by deubiquitinating and thereby stabilizing CLSPN - a protein that is ubiquitinated by the APC/C E3 Ubiquitin ligase in a cell-cycle dependent manner. USP28 interacts with isoform 1 of FBXW7 in the nucleoplasm, and regulates MYC degradation by counteracting its ubiquitination. Recently, a potential role in HIF-1 alpha -dependent processes such as angiogenesis and metastasis has been described for this deubiquitinase. USP28 has been demonstrated to cleave K6, K11, K48, and K63-linked poly-Ubiquitin chains. This recombinant protein contains a C-terminal 6-His tag.

     

     

    • References:

      1. Basserman F.,         et al. (2008) Cell         134: 256-267.

      2. Flügel D.,         et al. (2012) Blood         119:1292-301.

      3. Popov N.,         et al. (2007) Cell Cycle         6: 2327-2331.

      4. Zhang D.,         et al. (2006) Cell         126: 529-542.

    • Long Name:

      Ubiquitin Specific Protease 28

    • Entrez Gene IDs:

      57646 (Human); 235323 (Mouse); 315639 (Rat)

    • Alternate Names:

      Deubiquitinating enzyme 28; EC 3.1.2.15; EC 3.4.19.12; KIAA1515ubiquitin carboxyl-terminal hydrolase 28; ubiquitin specific peptidase 28; ubiquitin specific protease 28; ubiquitin thioesterase 28; Ubiquitin thiolesterase 28; Ubiquitin-specific-processing protease 28; USP28




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