• Species Reactivity

  Human

• Specificity

  Detects human CD1a in direct ELISAs. In direct ELISAs, less than 5% cross-reactivity with recombinant human (rh) CD1d is observed and no cross-reactivity with with rhCD1b or rhCD1e is observed.

• Source

  Monoclonal Mouse IgG1 Clone # 703217

• Immunogen

  Mouse myeloma cell line NS0-derived recombinant human CD1a    
  Asp19-Val300 (predicted)    
  Accession # P06126

• Formulation

  Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

• Label

  Alexa Fluor 750

Applications

• Recommended    
  Concentration

  Sample

• Flow Cytometry

  0.25-1 µg/10    ⁶ cells

  MOLT‑4 human acute lymphoblastic leukemia cell line

• 
  

Please Note: Optimal dilutions should be determined by each laboratory for each application.  are available in the Technical Information section on our website.

Preparation and Storage

• Shipping

  The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

• Stability & Storage

  Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: CD1a

CD1a is a 49 kDa transmembrane glycoprotein in the CD1 family of glycolipid antigen-presenting MHC-like molecules. CD1a contains one Ig-like domain in its extracellular region. It is expressed by most nonhuman mammals but not by mice or rats. Complexes of CD1a with beta 2-microglobulin and endogenous glycolipids are constitutively expressed on antigen presenting cells, cortical thymocytes, and Langerhans cells. CD1a is a target of autoreactive Th22 helper T cells in the skin.

• Long Name:

  T Cell Surface Glycoprotein CD1a

• Entrez Gene IDs:

  909 (Human)

• Alternate Names:

  CD1; CD1a antigen; CD1A antigen, a polypeptide; CD1a molecule; CD1a; cluster of differentiation 1 A; cortical thymocyte antigen CD1A; differentiation antigen CD1-alpha-3; epidermal dendritic cell marker CD1a; FCB6; hTa1 thymocyte antigen; HTA1; R4; T6; T-cell surface antigen T6/Leu-6; T-cell surface glycoprotein CD1a