• Species Reactivity

  Human

• Specificity

  Detects human NKG2C/CD159c. Detects human NKG2C/CD159c as part of the NKG2C/CD94 heterodimer in flow cytometry. No    
  cross-reactivity with the human NKG2A/CD94 heterodimer or with the human CD94 homodimer is detected.

• Source

  Monoclonal Mouse IgG2b Clone # 134522

• Immunogen

  BaF3 mouse pro-B cell line transfected with human NKG2C/CD159c and CD94

• Formulation

  Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

• Label

  Alexa Fluor 750

Applications

• Recommended    
  Concentration

  Sample

• Flow Cytometry

  0.25-1 µg/10    ⁶ cells

  Human peripheral blood lymphocytes

• 
  

Please Note: Optimal dilutions should be determined by each laboratory for each application.  are available in the Technical Information section on our website.

Preparation and Storage

• Shipping

  The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

• Stability & Storage

  Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: NKG2C/CD159c

NKG2C, also known as hemoglobin scavenger receptor, is a type I transmembrane protein expressed exclusively in monocytes and macrophages. It is a scavenger receptor cysteine-rich superfamily (SRCR-SF) protein that contains nine SRCR motifs in its extracellular region. MAB1381 displays potent agonistic activity and also blocks the binding of the NKG2C/CD94 heterodimer to HLA-E tetramers (1-3).

• References:

1. Alici, E. et al. (2008) Blood 111:3155.

2. Coupel, S. et al. (2007) Blood 109:2806.

3. Fausther-Bovendo, H. et al. (2008) AIDS 22:217.

• Long Name:

  Natural Killer G2C

• Entrez Gene IDs:

  3822 (Human); 16642 (Mouse)

• Alternate Names:

  CD159 antigen-like family member C; CD159c antigen; CD159c; killer cell lectin-like receptor subfamily C, member 2; KLRC2; MGC138244; NK cell receptor C; NKG2-C type II integral membrane protein; NKG2C; NKG2-C; NKG2CNKG2-C-activating NK receptor