• Species Reactivity

  Human

• Specificity

  Detects human SIRP beta 1/CD172b in direct ELISAs and Western blots.

• Source

  Monoclonal Mouse IgG2a Clone # 308906

• Immunogen

  Mouse myeloma cell line NS0-derived recombinant human SIRP beta 1/CD172b    
  Gly26-Ala369 (Arg53His and Ala363Pro)    
  Accession # O00241.4

• Formulation

  Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

• Label

  Alexa Fluor 700

Applications

• Recommended    
  Concentration

  Sample

• Flow Cytometry

  0.25-1 µg/10    ⁶ cells

  Human whole blood

• 
  

Please Note: Optimal dilutions should be determined by each laboratory for each application.  are available in the Technical Information section on our website.

Preparation and Storage

• Shipping

  The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

• Stability & Storage

  Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: SIRP beta 1/CD172b

SIRP beta 1 is a type I transmembrane protein belonging to the SIRP family within the Ig superfamily. Members of this family are characterized by an extracellular region containing a V-set Ig domain containing a J-like sequence and two C1-set Ig domains. Unlike SIRP alpha that has cytoplasmic ITIM domains, SIRP beta 1 possesses positively charged residues that allow association with ITAM motif containing adaptor molecules. SIRP beta 1 is expressed on cells of monocyte, macrophage or dendritic lineages.

• Long Name:

  Signal-regulatory Protein beta 1

• Entrez Gene IDs:

  10326 (Human)

• Alternate Names:

  CD172 antigen-like family member B; CD172b antigen; CD172b; DKFZp686A05192; FLJ26614; signal-regulatory protein beta 1; signal-regulatory protein beta-1; SIRP beta 1; SIRPB1; SIRP-beta-1 isoform 3; SIRP-BETA-1