• Species Reactivity

  Human

• Specificity

  Detects human SerpinA11 in ELISA and Western Blot.

• Source

  Monoclonal Mouse IgG    _2B Clone # 895842

• Purification

  Protein A or G purified from hybridoma culture supernatant

• Immunogen

  Chinese hamster ovary cell line CHO-derived recombinant human SerpinA11    
  Met1-Gly422    
  Accession # Q86U17

• Formulation

  Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

• Label

  Unconjugated

Applications

• 
  

  Recommended    
  Concentration

  Sample

• Western Blot

  1 µg/mL

  See below

• 
  

Please Note: Optimal dilutions should be determined by each laboratory for each application.  are available in the Technical Information section on our website.

Data Examples

Preparation and Storage

• Reconstitution

  Reconstitute at 0.5 mg/mL in sterile PBS.

• Shipping

  The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

• Stability & Storage

  Use a manual defrost freezer and avoid repeated freeze-thaw cycles.    

• 12 months from date of receipt, -20 to -70 °C as supplied.

• 1 month, 2 to 8 °C under sterile conditions after reconstitution.

• 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Serpin A11

Serpin A11 (serine proteinase inhibitor – clade A#11) is a 50-60 kDa secreted member of the serpin superfamily of protease inhibitors.  Serpins are the largest family of endogenous protease inhibitors, and target a wide variety of serine and cysteine proteases.  In general, members of this superfamily regulate multiple proteolytic cascades, and are particularly effective due to the fact that their inhibitory activities can be fine-tuned through the participation of discrete, non-serpin co-factors.  Serpin A11 gene expression is extremely high in normal liver, with lower levels detected in normal breast, breast tumor, and benign prostatic hyperplasia.  Human Serpin A11 is 422 amino acids (aa) in length, with four potential N-linked glycosylation sites, and shares 75% aa sequence identity with mouse Serpin A11.

• Long Name:

  Serpin Peptidase Inhibitor, Clade A, Member 11

• Entrez Gene IDs:

  256394 (Human); 380780 (Mouse); 362774 (Rat)

• Alternate Names:

  Antiproteinase-Like 2; antitrypsin), member 11; member 11; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase; Serpin A11; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin)