• Species Reactivity

  Human

• Specificity

  Detects human Transthyretin/Prealbumin in direct ELISAs and Western blots.

• Source

  Monoclonal Mouse IgG    ₁ Clone # 760430

• Purification

  Protein A or G purified from hybridoma culture supernatant

• Immunogen

  Human Transthyretin/Prealbumin    
   

• Formulation

  Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

• Label

  Unconjugated

Applications

• 
  

  Recommended    
  Concentration

  Sample

• Western Blot

  2 µg/mL

  See below

• 
  

• Immunocytochemistry

  8-25 µg/mL

  See below

• 
  

Please Note: Optimal dilutions should be determined by each laboratory for each application.  are available in the Technical Information section on our website.

Data Examples

Preparation and Storage

• Reconstitution

  Sterile PBS to a final concentration of 0.5 mg/mL.

• Shipping

  The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

• Stability & Storage

  Use a manual defrost freezer and avoid repeated freeze-thaw cycles.    

• 12 months from date of receipt, -20 to -70 °C as supplied.

• 1 month, 2 to 8 °C under sterile conditions after reconstitution.

• 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Transthyretin/Prealbumin

Transthyretin (TTR), previously called thyroxin-binding prealbumin, is a 55 kDa homotetramer of 14-15 kDa monomers that is found in plasma. TTR is responsible for the transport of the thyroid hormone T4 and retinol binding protein (RBP). It slows renal clearance of T4 and RBP due to megalin-mediated re-uptake of TTR complexes in the renal tubules. TTR is also found in tissues including the brain. Numerous human polymorphisms have been associated with aggregates found in familial amyloidotic polyneuropathies (FAP). Mature human TTR shares 80% and 83% amino acid sequence identity with mouse and rat TTR, respectively.

• Entrez Gene IDs:

  7276 (Human)

• Alternate Names:

  ATTR; HsT2651; PALB; PALBTBPA; Prealbumin; prealbumin, amyloidosis type I; TBPA; thyroxine-binding prealbumin; Transthyretin; TTR