• Species Reactivity

  Human

• Specificity

  Detects human Dopamine D2 R/DRD2 in direct ELISAs.    
   

• Source

  Monoclonal Mouse IgG    ₁ Clone # 960710

• Purification

  Protein A or G purified from hybridoma culture supernatant

• Immunogen

  Human DRD2 synthetic peptide    
  Accession # P14416

• Formulation

  Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

• Label

  Unconjugated

Applications

• 
  

  Recommended    
  Concentration

  Sample

• Immunohistochemistry

  5-25 µg/mL

  See below

• 
  

Please Note: Optimal dilutions should be determined by each laboratory for each application.  are available in the Technical Information section on our website.

Data Examples

Preparation and Storage

• Reconstitution

  Reconstitute at 0.5 mg/mL in sterile PBS.

• Shipping

  The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

• Stability & Storage

  Use a manual defrost freezer and avoid repeated freeze-thaw cycles.    

• 12 months from date of receipt, -20 to -70 °C as supplied.

• 1 month, 2 to 8 °C under sterile conditions after reconstitution.

• 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Dopamine D2 R/DRD2

Dopamine receptor D2 (DRD2) is localized to human striatum, motor cortex and neocortex. It is a highly conserved seven transmembrane receptor member of the G-protein coupled receptor 1 family, with three known isoforms. In the striatum, DRD2 suppresses voluntary activity in the striatopallidal pathway, and polymorphisms in this gene are associated with alcohol addiction, smoking behavior, schizophrenia, food addiction and post-traumatic stress disorder as well as myoclonus dystonia.  DRD2 has been shown to heterodimerize with DDR4 and 5-HT2A receptors, and traffics between the plasma membrane and intracellular pools and this localization can be modulated by several drugs.  DRD2 is localized to human striatum, motor cortex and neocortex.

• Long Name:

  Dopamine D2 Receptor

• Entrez Gene IDs:

  1813 (Human); 13489 (Mouse); 24318 (Rat)

• Alternate Names:

  D(2) dopamine receptor; D2DR; D2R; Dopamine D2 R; Dopamine D2 receptor; Dopamine D2R; dopamine receptor D2 isoform; dopamine receptor D2; DRD2; seven transmembrane helix receptor