Human Meprin alpha Subunit/MEP1A Alexa Fluor 647 Antibody 100 UG

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Human Meprin alpha Subunit/MEP1A Alexa Fluor 647 Antibody 100 UG信息二维码

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产品介绍

    基本参数

    详细说明

    • Species Reactivity

      Human

    • Specificity

      Detects human Meprin alpha Subunit/MEP1A in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human MEP1B or recombinant mouse MEP1A is observed.

    • Source

      Monoclonal Mouse IgG2b Clone # 364312

    • Immunogen

      Mouse myeloma cell line NS0-derived recombinant human Meprin alpha Subunit/MEP1A    
      Val22-Gln601    
      Accession # AAA21338

    • Formulation

      Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

    • Label

      Alexa Fluor 647

    Applications


    • Recommended    
      Concentration

      Sample

    • Intracellular Staining by Flow Cytometry

      0.25-1 µg/10    6 cells

      HEK293 human embryonic kidney cell line fixed with paraformaldehyde and permeabilized with saponin


    Please Note: Optimal dilutions should be determined by each laboratory for each application.  are available in the Technical Information section on our website.

    Preparation and Storage

    • Shipping

      The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

    • Stability & Storage

      Store the unopened product at 2 - 8 °C. Do not use past expiration date.

    Background: Meprin alpha Subunit/MEP1A

    Meprins are multimeric proteases composed of alpha  and beta  subunits, which are members of the astacin family of zinc endopeptidases (1, 2). Both subunits form disulfide‑linked homo- or heterooligomers, which are also referred to as Meprin A (composed of alpha  subunits with or without beta  subunits) and Meprin B (composed of beta  subunits only) (3). Although the two subunits share 42% identity in their amino acid (aa) sequence, they differ significantly in their oligomeric structure, post-translational processing and subsequently cellular location, and substrate and peptide bond specificity (4). Human Meprin alpha  subunit consists of a signal peptide (aa 1 to 21), a pro region (aa 22 to 65), and a mature chain (aa 66 to 746) containing the following domains: catalytic (aa 62 to 263), MAM (aa 264 to 433), MATH (aa 434 to 593), EGF-like (aa 670 to 710), transmembrane (aa 713 to 740), and cytoplasmic (aa 741 to 746).

    • References:

        1. Bond, J.S. and Beynon, R.J. (1995) Protein Sci. 4:1247.

        2. Stocker, W. et al. (1995) Protein Sci. 4:823.

        3. Bertenshaw, G.P., et al. (2001) J. Biol. Chem. 276:13248.

        4. Ishmael, F.T. et al. (2005) J. Biol. Chem. 280:13895.

      1. Entrez Gene IDs:

        4224 (Human); 17287 (Mouse); 25684 (Rat)

      2. Alternate Names:

        bA268F1.1 (meprin A alpha (PABA peptide hydrolase)); EC 3.4.24; EC 3.4.24.18; endopeptidase-2; MEP1A; meprin A subunit alpha; meprin A, alpha (PABA peptide hydrolase); Meprin alpha Subunit; N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha; PABA peptide hydrolase; PPH alpha; PPHA


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