Human MDL-1/CLEC5A Alexa Fluor 647 Antibody (Clone 283834) 100 UG

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Human MDL-1/CLEC5A Alexa Fluor 647 Antibody (Clone 283834) 100 UG信息二维码

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产品介绍

    基本参数

    详细说明

    • Species Reactivity

      Human

    • Specificity

      Detects human MDL‑1/CLEC5A in Western blots. Does not cross-react with recombinant mouse MDL‑1.

    • Source

      Monoclonal Mouse IgG2b Clone # 283834

    • Immunogen

      Mouse myeloma cell line NS0-derived recombinant human MDL‑1/CLEC5A    
      Tyr26-Lys188    
      Accession # Q9NY25

    • Formulation

      Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

    • Label

      Alexa Fluor 647

    Applications


    • Recommended    
      Concentration

      Sample

    • Flow Cytometry

      0.25-1 µg/10    6 cells

      Human peripheral blood granulocytes


    Please Note: Optimal dilutions should be determined by each laboratory for each application.  are available in the Technical Information section on our website.

    Preparation and Storage

    • Shipping

      The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

    • Stability & Storage

      Store the unopened product at 2 - 8 °C. Do not use past expiration date.

    Background: MDL-1/CLEC5A

    MDL-1 is an approximately 40 kDa transmembrane glycoprotein belonging to the C-type lectin superfamily (CLEC5A). MDL-1 is expressed on immature myeloid cells, monocytes, macrophages, dendritic cells, neutrophils, NK cells, and osteocytes. It contains a charged lysine in the transmembrane region that enables it to associate with DAP12 and deliver an activating signal. MDL-1 mediates inflammatory responses during autoimmune arthritis and upon binding to Dengue and Japanese encephalitis viruses. The extracellular domain (ECD) of MDL-1 contains a juxtamembrane stalk region and one C-type lectin domain. Within the ECD, human and mouse MDL-1 share 67% amino acid sequence identity.

    • Long Name:

      Myeloid DAP12-associating Lectin

    • Entrez Gene IDs:

      23601 (Human); 23845 (Mouse)

    • Alternate Names:

      CLEC5A; CLECSF5; CLECSF5carbohydrate-recognition domain) lectin, superfamilymember 5; C-type lectin domain family 5, member A; C-type lectin superfamily member 5; MDL1; MDL-1; MDL-1MGC138304; Myeloid DAP12-associating lectin 1; myeloid DAP12-associating lectin-1






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