Human IL-37/IL-1F7 Alexa Fluor 594 Antibody (Clone 899826) 100 UG

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Human IL-37/IL-1F7 Alexa Fluor 594 Antibody (Clone 899826) 100 UG信息二维码

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产品介绍

    基本参数

    详细说明

    • Species Reactivity

      Human

    • Specificity

      Detects human IL-37/IL-1F7 in ELISAs.

    • Source

      Monoclonal Mouse IgG    2B Clone # 899826

    • Purification

      Protein A or G purified from hybridoma culture supernatant

    • Immunogen

      E. coli-derived recombinant human IL-37/IL-1F7    
      Lys53-Val206    
      Accession # Q9NZH6

    • Formulation

      Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

    • Label

      Alexa Fluor 594

    Applications


    • Recommended    
      Concentration

      Sample

    • Intracellular Staining by Flow Cytometry

      0.25-1 µg/10    6 cells

      Human peripheral blood mononuclear cell (PBMC) monocytes treated with LPS and monensin fixed with Flow Cytometry Fixation Buffer (Catalog # ) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (Catalog # )


    Please Note: Optimal dilutions should be determined by each laboratory for each application.  are available in the Technical Information section on our website.

    Preparation and Storage

    • Shipping

      The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

    • Stability & Storage

      Protect from light.    Do not freeze.    

      • 12 months from date of receipt, 2 to 8 °C as supplied.

    Background: IL-37/IL-1F7

    Human Interleukin 1 Family Member 7 (IL-1F7), also named IL-37, FIL-1Z, IL-1H4, and IL-1RP1, belongs to the IL-1 cytokine family.  With the exception of IL-18 that maps to human chromosome 11, all other IL-1 family members map to the same cluster on human chromosome 2. Five alternatively spliced transcripts that arise through alternate exon usage have been described. These transcripts encode five different IL-1F7 isoforms (IL-1F7a through e also referred to as isofoms 1 through 5) that have distinct expression profiles. Polymorphism in the protein sequence of IL-1F7 isoforms also exists. Like IL-1 alpha, IL-1 beta and IL-18, all of the IL-1F7 variants lack a typical signal peptide. The longest IL-1F7 transcript, referred to as IL-1F7b or IL-1F7 isoform 1, encodes a 218 amino acid (aa) residues proprotein containing a 45 aa propeptide, which is removed by caspase-1 to generate the 173 aa mature segment. Mature IL-1F7b and other IL-1F7 variants lack potential N-linked glycosylation sites. IL-1F7 shares approximately 21%, 24%, and 30% aa sequence identity with mature IL-1 alpha, IL-1 beta and IL-1ra, respectively. Mouse IL-1F7 has not been reported, but human IL-1F7 is active on mouse cells. IL-1F7b binds to IL-18 R alpha with low affinity but does not exert any IL-18 agonistic or antagonistic effects. IL-1F7b also binds to the IL-18BP to enhance the antagonistic effects of IL-18BP. It has been proposed that IL-1F7b form a trimeric complex with IL-18BP and IL-18 R beta. This complex blocks IL-18 activity by sequestering the signal transducing subunit and preventing it from participating in IL-18 signaling (1‑8).

    • References:

      1. Smith, D.E. et al. (2000) J. Biol. Chem. 275:1169.

      2. Kumar S. et al. (2000) J. Biol. Chem. 275:10308.

      3. Busfield S.J. et al. (2000) Genomics 66:213.

      4. Kumar S. et al. (2002) Cytokine 18:61.

      5. Bufler, P. et al. (2002) Proc. Natl. Acad. Sci. USA 99:13723.

      6. Gao, W. et al. (2003) J. Immunol. 170:1077.

      7. Pan, G. et al. (2001) Cytokine 13:1.

      8. Sims, J.E. et al. (2001) Trends Immunol. 22:533.

    • Long Name:

      Interleukin 37

    • Entrez Gene IDs:

      27178 (Human)

    • Alternate Names:

      FIL1 zeta; FIL1; FIL1(ZETA); FIL1ZFIL1 zeta; IL-1F7; IL-1F7IL-1 zeta; IL1H4IL1F7 (canonical product IL-1F7b); IL-1H4IL-1F7b (IL-1H4, IL-1H, IL-1RP1); IL-1RP1IL-1X protein; IL1RP1interleukin 1 family member 7; IL-1X; IL37; IL-37; interleukin 1 family, member 7 (zeta); interleukin 1, zeta; interleukin-1 family member 7; Interleukin-1 homolog 4; interleukin-1 superfamily z; Interleukin-1 zeta; Interleukin-1-related protein


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