• Species Reactivity

  Human

• Specificity

  Detects human S1P    ₁/EDG‑1 by flow cytometry.

• Source

  Monoclonal Mouse IgG2b Clone # 218713

• Immunogen

  NS0 mouse myeloma cell line transfected with human S1P    ₁/EDG‑1    
  Met1-Ser382    
  Accession # P21453

• Formulation

  Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

• Label

  Alexa Fluor 350

Applications

• 
  

  Recommended    
  Concentration

  Sample

• Flow Cytometry

  0.25-1 µg/10    ⁶ cells

  CHO Chinese hamster ovary cell line transfected with human S1P    ₁/EDG-1 and eGFP

• 
  

Please Note: Optimal dilutions should be determined by each laboratory for each application.  are available in the Technical Information section on our website.

Preparation and Storage

• Shipping

  The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

• Stability & Storage

  Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: S1P1/EDG-1

S1P  ₁, also known as EDG-1, is a member of the endothelial differentiation gene family. It is a high affinity G protein-coupled receptor for the bioactive lipid, Sphingosine-1-phosphate. S1P  ₁ signaling regulates endothelial cell survival, cytoskeletal remodeling, chemotaxis, and angiogenesis.

• Long Name:

  Endothelial Differentiation Gene 1

• Entrez Gene IDs:

  1901 (Human); 13609 (Mouse)

• Alternate Names:

  CD363 antigen; CD363; CHEDG1; D1S3362; EDG1; EDG-1; EDG1edg-1; Endothelial differentiation G-protein coupled receptor 1; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; FLJ58121; S1P receptor 1; S1P receptor Edg-1; S1P1; S1P1ECGF1; S1PR1; sphingosine 1-phosphate receptor 1; sphingosine 1-phosphate receptor EDG1; Sphingosine 1-phosphate receptor Edg-1; sphingosine-1-phosphate receptor 1