详细说明
| Replacement Information |
|---|
重要规格表
| Species Reactivity | Key Applications | Analytes Available | Detection Methods |
|---|---|---|---|
| H, M | KA | PI 3-Kinase | HTRF |
| Description | |
|---|---|
| Catalogue Number | 33-041 |
| Brand Family | Upstate |
| Trade Name |
|
| Description | PI 3-Kinase 3-step HTRF™ Assay |
| References |
|---|
| Product Information | |
|---|---|
| Components |
|
| Detection method | HTRF |
| Applications | |
|---|---|
| Application | Everything you need to perform the PI3 Kinase 3-step HTRF assays (1920 wells). |
| Key Applications |
|
| Biological Information | |
|---|---|
| Species Reactivity |
|
| Analytes Available |
|
| Entrez Gene Number |
|
| Entrez Gene Summary | Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. |
| Gene Symbol |
|
| Target Sub-Family | PI3K/PI4K |
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: P42336 # Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2. SIZE: 1068 amino acids; 124284 Da SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Binds to IRS1 in nuclear extracts. Interacts with RUFY3 (By similarity). DISEASE: SwissProt: P42336 # Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500]. & Defects in PIK3CA are associated with breast cancer [MIM:114480]. & Defects in PIK3CA are associated with epithelial ovarian cancer (EOC) [MIM:604370]. SIMILARITY: SwissProt: P42336 ## Belongs to the PI3/PI4-kinase family. & Contains 1 C2 domain. & Contains 1 PI3K/PI4K domain. |
| Physicochemical Information |
|---|
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements | |
|---|---|
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | 12 months at -70°C |
| Packaging Information | |
|---|---|
| Material Size | 1920 wells |
| Material Package | Kit capacity: 1920 wells |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
粤公网安备44196802000105号
400-6226-992