没食子酸甲酯,英文名:Methyl gallate,CAS:99-24-1,化学式:C8H8O5,分子量:184.15,密度:1.3840 (rough estimate),熔点:201-204°C,

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99-24-1 询问

没食子酸甲酯(Methyl gallate)

CAS: 99-24-1

化学式: C8H8O5

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中文名	没食子酸甲酯
英文名	Methyl gallate
别名	三羟基苯甲酸 没食子酸甲酯 没食子酸甲酯(五倍子酸甲酯 3,4,5-三羟基苯甲酸甲酯 S**3,4,5-三羟基苯甲酸甲酯
英文别名	METHYGALLATE Methyl gallate METHYLGALLATE(RG) Methyl 3,4,5-trihydroxybenzoate methyl 3,4,5-trihydroxy benzoate 3,4,5-trihydroxy-benzoic acidd methyl ester METHYL GALLATE(METHYL 3,4,5-TRIHYDROXYBENZOATE ) 2-diazo-1-naphthol-5-sulfonic acid, ester with novolac Gallic acid methyl ester, Methyl 3,4,5-trihydroxybenzoate 3,4,5-trihydroxybenzoic acid methyl ester (intermediate of bifendate)
CAS	99-24-1
EINECS	202-741-7
化学式	C8H8O5
分子量	184.15
InChI	InChI=1/C8H8O5/c1-13-8(12)4-2-5(9)7(11)6(10)3-4/h2-3,9-11H,1H3
InChIKey	FBSFWRHWHYMIOG-UHFFFAOYSA-N
密度	1.3840 (rough estimate)
熔点	201-204°C
沸点	278.08°C (rough estimate)
闪点	190.8°C
水溶性	SOLUBLE IN HOT WATER
蒸汽压	1.02E-08mmHg at 25°C
溶解度	乙醇: 50mg/ml，澄清
折射率	1.5690 (estimate)
酸度系数	8.04±0.23(Predicted)
存储条件	Inert atmosphere,Room Temperature
敏感性	Easily absorbing moisture
外观	结晶性粉末
颜色	White to slightly beige
Merck	14,4345
BRN	2113180
物化性质	单斜棱状结晶（甲醇）。熔点为201-203℃（157℃，水合物或溶剂化的结晶）。溶于热水、乙醇、乙醚。
MDL号	MFCD00002194
体外研究	The growth of A. viscosus is inhibited completely by a low dose of Methyl gallate (MIC=1 mg/mL). S. mutans and . sobrinus show intermediate sensitivity to Methyl gallate (MIC=2-4 mg/mL), whereas the growth of Lactobacillus spp. is inhibited completely at a relatively high concentration (MIC=8 mg/mL). Methyl gallate, in a concentration of 100 mM, could alleviate lipid peroxidation of the cells exposed to a short-term H 2 O 2 treatment. In addition, Methyl gallate-treated cells could prevent intracellular glutathione (GSH) from being depleted following an exposure of H 2 O 2 (8.0 mM) for a 3 h period. Methyl gallate inhibits Treg cell-suppressive effects on effector CD4+ T cells and Treg migration toward tumor environment. Furthermore, forkhead box P3 (Foxp3) expression is also significantly decreased by methyl gallate.
危险品标志	Xn - 有害物品 Xi - 刺激性物品
风险术语	R22 - 吞食有害。 R36/37/38 - 刺激眼睛、呼吸系统和皮肤。 R43 - 与皮肤接触可能致敏。
安全术语	S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S36/37 - 穿戴适当的防护服和手套。 S24/25 - 避免与皮肤和眼睛接触。
WGK Germany	3
RTECS	LW8000000
TSCA	Yes
海关编号	29182900
上游原料	没食子酸
下游产品	没食子酸辛酯 3,4,5-三羥甲苯
参考资料 展开查看	1. 周坤, 简平, 梁文仪,等. 基于UPLC-Q-Exactive Orbitrap-MS分析藏药诃子与毛诃子化学成分[J]. 质谱学报, 2020, 041(003):254-267. 2. 梁文仪, 亓旗, 梁林金,等. 基于化学计量学分析的诃子药材高效液相色谱指纹图谱研究[J]. 世界科学技术-中医药现代化, 2018, 20(09):167-171. 3. 梁林金, 亓旗, 叶婷,等. 基于总鞣质和7种成分同时测定的诃子药材质量控制研究[J]. 世界科学技术:中医药现代化, 2018, 20(09):1638-1644. 4. Li-Mei Feng, Yan-Yan Chen, Ding-Qiao Xu, Rui-Jia Fu, Shi-Jun Yue, Qi Zhao, Yu-Xi Huang, Xue Bai, Mei Wang, Li-Ming Xing, Yu-Ping Tang, Jin-Ao Duan,An integrated strategy for discovering effective components of Shaoyao Gancao decoction for treating neuropa 5. Li-Mei Feng, Yan-Yan Chen, Ding-Qiao Xu, Rui-Jia Fu, Shi-Jun Yue, Qi Zhao, Yu-Xi Huang, Xue Bai, Mei Wang, Li-Ming Xing, Yu-Ping Tang, Jin-Ao Duan,An integrated strategy for discovering effective components of Shaoyao Gancao decoction for treating neuropa 6. [IF=4.952] Ren-You Gan et al."Pigmented edible bean coats as natural sources of polyphenols with antioxidant and antibacterial effects."Lwt Food Sci Technol. 2016 Nov;73:168 7. [IF=3.935] Li Li et al."Rapid identification of urokinase plasminogen activator inhibitors from Traditional Chinese Medicines based on ultrafiltration, LC–MS and in silico docking."J Pharmaceut Biomed. 2019 Feb;164:241 8. [IF=6.312] Yue Zhou et al."Optimization of Ultrasound-Assisted Extraction of Antioxidant Polyphenols from the Seed Coats of Red Sword Bean (Canavalia gladiate (Jacq.) DC.)."Antioxidants-Basel. 2019 Jul;8(7):200 9. [IF=5.645] Zhang-Zhen Bai et al."Comparative investigation on metabolites and biological activities of Paeonia ostii stamens from different geographical regions of China."Ind Crop Prod. 2021 Nov;172:114038 10. [IF=4.36] Li-Mei Feng et al."An integrated strategy for discovering effective components of Shaoyao Gancao decoction for treating neuropathic pain by the combination of partial least-squares regression and multi-index comprehensive method."J Ethnopharmacol. 2020 Oc 11. [IF=5.246] Wei Gu et al."Investigation of Tannins Transformation in Sanguisorbae Radix Over Carbonizing by Stir-Frying."Front Mol Biosci. 2022; 9: 762224

99-24-1 - 简介

没食子酸甲酯（Methyl gallate）是一种有机化合物。它是没食子酸和甲醇反应而得到的酯类化合物。

没食子酸甲酯的性质：
- 外观：红色或橙色结晶固体。
- 溶解性：易溶于乙醇、丙酮和乙醚，不溶于水。

没食子酸甲酯的用途：

没食子酸甲酯的制法：
没食子酸甲酯可以通过没食子酸和甲醇的酯化反应得到。反应条件一般是在加热条件下，使用酸性催化剂进行。

没食子酸甲酯的安全信息：
- 这种化合物属于低毒化合物，但应注意避免接触皮肤和吸入。
- 使用过程中应注意防护措施，戴手套和防护眼镜等。
- 储存时应避免高温、火源和阳光直射。
在使用前请仔细阅读相关标签和安全说明，并严格按照操作规程进行。最后更新：2024-04-09 15:16:52