427-51-0
环丙氯地孕酮(Cyproterone acetate)
CAS: 427-51-0
化学式: C24H29ClO4
| 中文名 | 环丙氯地孕酮 |
| 英文名 | Cyproterone acetate |
| 别名 | 环丙氯地孕酮 醋酸环丙氯地孕酮 环丙氯地孕酮醋酸酯 醋酸环丙孕酮(标准品) 醋酸环丙孕酮,醋酸环丙氯地孕酮 环丙氯地孕酮醋酸酯(环丙氯地孕酮) 环丙孕酮醋酸盐, 一种雄激素受体拮抗剂 6-氯-1α,2α-亚甲基-4,6-孕甾二烯-17α-羟基-3,20-二酮-17-醋酸酯 |
| 英文别名 | SH 714 SH 80714 Androcur NSC-81430 HSDB 3592 NSC 81430 Cyprostat CCRIS 4385 UNII-4KM2BN5JHF Cyproteron acetate Cyproterone acetate cyprosteroneacetate Cyproteron-R acetate Cyproterone 17-O-acetate Cyproterone 17alpha-acetate 6-Chloro-delta-6-1,2alpha-methylene-17alpha-hydroxyprogesterone acetate 20-dione,6-chloro-17-hydroxy-1-alpha,2-alpha-methylene-pregna-6-diene-3 6)-pregnadiene-17-alpha-ol-3,20-dione17-2-alpha-methylene-6-chloro-(sup4 1,2-alpha-methylene-6-chloro-pregna-4,6-diene-3,20-dione17-alpha-acetate 6-chlor-delta(sup6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteronacetat 6-Chlor-delta(sup 6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteronacetat 1,2-alpha-Methylene-6-chloro-pregna-4,6-diene-3,20-dione 17-alpha-acetate 1,2-alpha-methylene-6-chloro-delta(sup6)-17-alpha-hydroxyprogesteroneacetat 6-Chloro-1,2-alpha-methylene-6-dehydro-17-alpha-hydroxyprogesterone acetate 1,2-alpha-methylene-6-chloro-delta-(sup4,6)-pregnadiene-17-alpha-ol-3,20-dio 17-alpha-acetoxy-6-chloro-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dio 1,2-alpha-Methylene-6-chloro-delta(sup 6)-17-alpha-hydroxyprogesterone acetate 6-Chloro-delta(sup 6)-1,2-alpha-methylene-17-alpha-hydroxyprogesterone acetate 17-alpha-Acetoxy-6-chloro-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dione 6-Chloro-1,2-alpha-methylene-17-alpha-hydroxy-delta(sup 6)-progesterone acetate 6-Chloro-17-hydroxy-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dione acetate 6-Chlor-delta(sup 6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteronacetat [German] Pregna-4,6-diene-3,20-dione, 6-chloro-17-hydroxy-1-alpha,2-alpha-methylene-, acetate 1,2-alpha-Methylene-6-chloro-(sup 4,6)-pregnadiene-17-alpha-ol-3,20-dione 17-alpha-acetate 6-Chloro-1beta,2beta-dihydro-17-hydroxy-3'H-cyclopropa(1,2)-pregna-1,4,6-triene-3,20-dione acetate 6-Chloro-1-beta,2-beta-dihydro-17-hydroxy-3'H-cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione 17-acetate 3'H-Cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 6-chloro-1-beta,2-beta-dihydro-17-hydroxy-, acetate 3'H-Cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 17-(acetyloxy)-6-chloro-1,2-dihydro-, (1beta,2beta)- (1R,7aR,8aS,8bS,10aS)-1-acetyl-5-chloro-8b,10a-dimethyl-7-oxo-1,2,3,3a,3b,7,7a,8,8a,8b,8c,9,10,10a-tetradecahydrocyclopenta[a]cyclopropa[g]phenanthren-1-yl acetate |
| CAS | 427-51-0 |
| EINECS | 207-048-3 |
| 化学式 | C24H29ClO4 |
| 分子量 | 416.94 |
| InChI | InChI=1/C24H29ClO4/c1-12(26)24(29-13(2)27)8-6-16-14-10-20(25)19-11-21(28)15-9-18(15)23(19,4)17(14)5-7-22(16,24)3/h10-11,14-18H,5-9H2,1-4H3/t14?,15-,16?,17?,18+,22+,23+,24+/m1/s1 |
| 密度 | 1.0677 (rough estimate) |
| 熔点 | 200-201°C |
| 沸点 | 528.8°C (rough estimate) |
| 闪点 | 177.6°C |
| 蒸汽压 | 3.78E-11mmHg at 25°C |
| 溶解度 | 几乎不溶于水，极易溶于二氯甲烷，易溶于丙酮，易溶于甲醇，微溶于无水乙醇。 |
| 折射率 | 1.4429 (estimate) |
| 存储条件 | Sealed in dry,Store in freezer, under -20°C |
| 外观 | 整洁 |
| 颜色 | White to Off-White |
| 最大波长(λmax) | ['281nm(MeOH)(lit.)'] |
| Merck | 14,2774 |
| 体外研究 | Cyproterone acetate具有显著的拮抗性能，也具有部分激活剂特性，在浓度相对较高时激活AR, EC50为4.0 μM。 在10 nM 睾丸激素存在时,低浓度Cyproterone acetate抑制T-刺激的3XHRE-LUC转录,但是高浓度时刺激转录。 |
| 体内研究 | Cyproterone acetate作用于生殖器官对重量有直接的负面影响，且显著降低精子数量和 CaCyproterone acetate处理，再加上在秋季认为延长白天，对精子活力和形态产生负影响。 Cyproterone acetate处理的雄激素受体优先降低睾丸中精细胞鱼精蛋白水平，也降低核染色质浓缩中涉及的精子水平。 |
| 危险品标志 | Xn - 有害物品 Xi - 刺激性物品 |
| 风险术语 | R20/21/22 - 吸入、皮肤接触及吞食有害。 R40 - 少数报道有致癌后果。 R36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
| 安全术语 | S22 - 切勿吸入粉尘。 S36 - 穿戴适当的防护服。 S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 |
| WGK Germany | 3 |
| RTECS | GZ2230000 |
| 海关编号 | 29372900 |
| 上游原料 | 醋酸 |
粤公网安备44196802000105号
400-6226-992