24345-16-2
蜂毒明肽(Apamin)
CAS: 24345-16-2
化学式: C79H131N31O24S4
| 中文名 | 蜂毒明肽 |
| 英文名 | Apamin |
| 别名 | 蜂毒明肽 蜂针液明肽 APAMIN毒素肽 毒素多肽APAMIN 蜂毒明肽 (蜂针液明肽) |
| 英文别名 | APAMIN Apamin APAMIN (HONEYBEE, APIS MELLIFERA) CYS-ASN-CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS-ALA-ARG-CYS-GLN-GLN-HIS-NH2 CYS-ASN-CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS-ALA-ARG-ARG-CYS-GLN-GLN-HIS-NH2 H-CYS-ASN-CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS-ALA-ARG-ARG-CYS-GLN-GLN-HIS-NH2 H-+CYS-ASN-++CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-+CYS-ALA-ARG-ARG-++CYS-GLN-GLN- HIS-NH2 H-Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 (Cys1-Cys11, Cys3-Cys15) |
| CAS | 24345-16-2 |
| EINECS | 246-182-7 |
| 化学式 | C79H131N31O24S4 |
| 分子量 | 2027.34 |
| InChI | InChI=1/C79H131N31O24S4/c1-35(2)26-49-70(127)107-51-31-136-135-30-41(81)63(120)105-50(28-57(84)114)71(128)108-53(73(130)99-42(12-7-8-22-80)64(121)96-38(5)77(134)110-25-11-15-54(110)75(132)102-47(18-21-58(115)116)69(126)109-59(39(6)111)76(133)95-37(4)62(119)104-49)33-138-137-32-52(106-66(123)44(14-10-24-92-79(88)89)98-65(122)43(13-9-23-91-78(86)87)97-61(118)36(3)94-72(51)129)74(131)101-45(16-19-55(82)112)67(124)100-46(17-20-56(83)113)68(125)103-48(60(85)117)27-40-29-90-34-93-40/h29,34-39,41-54,59,111H,7-28,30-33,80-81H2,1-6H3,(H2,82,112)(H2,83,113)(H2,84,114)(H2,85,117)(H,90,93)(H,94,129)(H,95,133)(H,96,121)(H,97,118)(H,98,122)(H,99,130)(H,100,124)(H,101,131)(H,102,132)(H,103,125)(H,104,119)(H,105,120)(H,106,123)(H,107,127)(H,108,128)(H,109,126)(H,115,116)(H4,86,87,91)(H4,88,89,92)/t36?,37-,38-,39+,41-,42-,43-,44?,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,59?/m0/s1 |
| 密度 | 1.63 |
| 沸点 | 847.17°C (rough estimate) |
| 溶解度 | 0.05 M乙酸: 5mg/ml，澄清，无色至淡黄色 |
| 折射率 | 1.5530 (estimate) |
| 存储条件 | -20°C |
| 外观 | 白色固体，带深褐色铸件 |
| Merck | 13,732 |
| MDL号 | MFCD00167944 |
| 体外研究 | Apamin (0.5-2 µg/mL; 24 hours; HSC-T6 cells) treatment markedly reduces the expression of α-SMA in the TGF-β1-induced HSC-T6 cells. Apamin treatment abrogats the activation of p-Smad2/3 and Smad4 induced by TGF-β1. Western Blot Analysis Cell Line: HSC-T6 cells Concentration: 0.5 µg/mL, 1 µg/mL and 2 µg/mL Incubation Time: 24 hours Result: Markedly reduced the expression of α-SMA in the TGF-β1-induced HSC-T6 cells. Abrogated the activation of p-Smad2/3 and Smad4 induced by TGF-β1. |
| 体内研究 | Apamin (0.1 mg/kg; intraperitoneal injection; twice a week; for 4 weeks; C57BL/6 male mice) treatment results in decreased liver injury and proinflammatory cytokine levels. Apamin suppresses the deposition of collagen, proliferation of BECs and expression of fibrogenic genes in the 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-fed mice. Animal Model: 8-week-old C57BL/6 male mice (20-25 g) with DDC feeding Dosage: 0.1 mg/kg Administration: Intraperitoneal injection; twice a week; for 4 weeks Result: Resulted in decreased liver injury and proinflammatory cytokine levels. Suppressed the deposition of collagen, proliferation of BECs and expression of fibrogenic genes in the DDC-fed mice. |
| 安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 |
| 危险品运输编号 | 2811 |
| WGK Germany | 3 |
| RTECS | CD6899900 |
| FLUKA BRAND F CODES | 3-10 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
24345-16-2 - 介绍
氨基酸序列 Cys-Asn-Cys-Lys-Ala-Pro-G?lu-Thr-Ala-Leu-Cys-Ala-Ar?g-Arg-Cys-Gln-Gln-His-NH2? [Disulfide Bridges: 1-11, 3-15]最后更新：2022-10-16 17:15:1324345-16-2 - 简介
蜂毒明肽是从蜂毒中提取的一种激活肽类物质。它具有多种生物活性，包括抗菌、抗炎、抗氧化和抗肿瘤等作用。蜂毒明肽的制法通常是从蜂毒中进行提取和纯化。首先收集蜜蜂蜇人后产生的蜂毒，经过一系列的分离和纯化步骤得到蜂毒明肽。常用的提取方法有溶剂提取、离子交换色谱和凝胶过滤等。
最后更新：2024-04-09 21:31:59
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