5-甲氧基黄酮,英文名:5-Methoxyflavone,CAS:42079-78-7,化学式:C16H12O3,分子量:252.26,密度:1,155g/cm,熔点:131-133°C,沸点:422_资料_文库

5-甲氧基黄酮,英文名:5-Methoxyflavone,CAS:42079-78-7,化学式:C16H12O3,分子量:252.26,密度:1,155g/cm,熔点:131-133°C,沸点:422

2024-10-31 0

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42079-78-7

5-甲氧基黄酮(5-Methoxyflavone)

CAS: 42079-78-7

化学式: C16H12O3

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中文名	5-甲氧基黄酮
英文名	5-Methoxyflavone
别名	甲氧基黄酮 5-甲氧基黄酮
英文别名	5-METHOXYFLAVONE 5-Methoxyflavone METHOXYFLAVONE, 5- 5-methoxy-2-phenyl-chromone 5-methoxy-2-phenylchromen-4-one 5-methoxy-2-phenyl-4-benzopyrone 5-methoxy-2-phenyl-chromen-4-one 5-Methoxy-2-phenyl-4H-1-benzopyran-4-one
CAS	42079-78-7
EINECS	255-652-0
化学式	C16H12O3
分子量	252.26
密度	1,155g/cm
熔点	131-133°C
沸点	422.5±45.0 °C(Predicted)
折射率	1,548
存储条件	2-8℃
敏感性	It will not decompose under normal conditions, and there is no dangerous reaction
外观	粉末
MDL号	MFCD00016942
体外研究	5-Methoxyflavone (compound 1) is identified as a candidate compound endowed with the ability to inhibit DNA pol-β in multiple and to prevent cell-cycle initiation and subsequent neuronal apoptosis in Aβ-challenged primary neuronal cultures. 5-methoxyflavone (10-30 μM) is able to significantly enhance toxicity of MMS on 92TAg cells. 5-Methoxyflavone (1 or 10 μM) significantly reduces polymerase activity on a gapped substrate. 5-Methoxyflavone (5-MF, 0-100 μg/mL) results in a time dependent reduction in the levels of antiapoptotic proteins cFLIP, Mcl-1 and an increase in the proapoptotic protein BAX. 5-MF induces both TRAIL-R1(DR4) and TRAIL-R2 (DR5) in a time-dependent manner.
体内研究	5-Methoxyflavone (100, 150 mg/kg, i.p) significantly decreases the latency time to loss of righting reflex. 5-Methoxyflavone (50, 100 and 150 mg/kg, i.p) exhibits a significant and dose-dependent reduction in the spontaneous locomotor activity. 5-Methoxyflavone (50, 100 mg/kg, i.p) reduces the rearing response. 5-Methoxyflavone (100, 125 and 150 mg/kg, i.p) completely abolishesed the grooming response similar to diazepam treated animals.
危险品标志	Xi - 刺激性物品
风险术语	36/37/38 - 刺激眼睛、呼吸系统和皮肤。
安全术语	S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。 S36 - 穿戴适当的防护服。
WGK Germany	3
下游产品	5-羟基黄酮

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