异甜菊醇,英文名:Isosteviol,CAS:27975-19-5,化学式:C20H30O3,分子量:318.45,密度:1.15±0.1 g/cm3(Predicted),熔点:228.0 to

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27975-19-5 询问

异甜菊醇(Isosteviol)

CAS: 27975-19-5

化学式: C20H30O3

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中文名	异甜菊醇
英文名	Isosteviol
别名	异甜菊醇 异斯特维醇 异甜菊醇对照品 异甜菊醇标准品 异甜菊醇, BR 异甜菊醇, 来源于甜叶菊 ISOSTEVIOL 异甜菊醇 ISOSTEVIOL 异甜菊醇 标准品
英文别名	CCRIS 6121 Nsc 231875 NSC 231875 ISOSTEVIOL Ccris 6121 Isosteviol Isosteviol (NSC 231875) 16-oxobeyeran-18-oic acid (4α,8β,13β)-13--Methyl-16-oxo-17-norkauran-18-oic acid 13-beta-kauran-18-oicacid,13-methyl-16-oxo-17-nor-8-bet 17-Nor-8-beta,13-beta-kauran-18-oic acid, 13-methyl-16-oxo- (4-alpha,8-beta,13-beta)-13-methyl-16-oxo-17-norkauran-18-oicacid (4-alpha,8-beta,13-beta)-13-Methyl-16-oxo-17-norkauran-18-oic acid 17-Norkauran-18-oic acid, 13-methyl-16-oxo-, (4-alpha,8-beta,13-beta)- 17-NORKAURAN-18-OIC ACID, 13-METHYL-16-OXO-, (4-ALPHA,8-BETA,13-BETA)-
CAS	27975-19-5
化学式	C20H30O3
分子量	318.45
InChI	InChI=1/C20H30O3/c1-17-9-5-14-18(2)7-4-8-19(3,16(22)23)13(18)6-10-20(14,12-17)11-15(17)21/h13-14H,4-12H2,1-3H3,(H,22,23)
密度	1.15±0.1 g/cm3(Predicted)
熔点	228.0 to 232.0 °C
沸点	455.6±38.0 °C(Predicted)
闪点	243.5°C
蒸汽压	1.44E-09mmHg at 25°C
溶解度	DMSO : ≥ 100 mg/mL (314.02 mM)
折射率	1.551
酸度系数	4.69±0.60(Predicted)
存储条件	Sealed in dry,Room Temperature
外观	整洁
颜色	White to Almost white
物化性质	白色结晶，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于甜菊（Stevia rebaudiana Bertoni）又名甜叶菊、甜草。
MDL号	MFCD28411514
体外研究	Isosteviol ((-)-Isosteviol) dose-dependently relaxed the vasopressin (10 -8 M)-induced vasoconstriction in isolated aortic rings with or without endothelium. However, in the presence of potassium chloride (3×10 -2 M), the vasodilator effect of isosteviol on arterial strips disappeared. Only the inhibitors specific for the ATP-sensitive potassium (KATP) channel or small conductance calcium-activated potassium (SKCa) channel inhibited the vasodilator effect of isosteviol in isolated aortic rings contracted with 10 -8 M vasopressin. The attenuation by isosteviol of the vasopressin- and phenylephrine-induced increase in [Ca 2+ ]i was inhibited by glibenclamide, apamin and 4-aminopyridine but not by charybdotoxin. Furthermore, the inhibitory action of isosteviol on [Ca 2+ ]i was blocked when A7r5 cells co-treated with glibenclamide and apamin in conjunction with 4-aminopyridine were present. Isosteviol (1-100 micromol/l) inhibits angiotensin-II-induced DNA synthesis and endothelin-1 secretion. Measurements of 2'7'-dichlorofluorescin diacetate, a redox-sensitive fluorescent dye, showed an isosteviol-mediated inhibition of intracellular reactive oxygen species generated by the effects of angiotensin II.
WGK Germany	3
参考资料 展开查看	1. [IF=3.738] Selma Houchi et al."Investigation of common chemical components and inhibitory effect on GES-type β-lactamase (GES22) in methanolic extracts of Algerian seaweeds."Microb Pathogenesis. 2019 Jan;126:56

27975-19-5 - 简介

异甜菊醇，也被称为苦草糖醇或叶甜素，是一种高度甜味的天然甜味剂。其性质如下：

味道甜度高：异甜菊醇的甜度约为蔗糖（白糖）的300-400倍，是一种强甜剂。与其他低热量甜味剂相比，异甜菊醇没有出现明显的苦味或其他刺激性感觉。

热稳定性强：异甜菊醇在高温条件下稳定，可在烹饪和烘烤过程中使用，并不会失去其甜度。

用途：

制法：
异甜菊醇的制法主要通过两步反应得到。从异甜菊植物中提取出总甜菊苷（主要成分为老千叶甙），然后经过水解和提纯工艺，得到甜菊糖醇（即异甜菊醇）。

安全信息： 但个别人可能对其过敏，对于那些对异甜菊醇过敏的人来说，摄入异甜菊醇可能引起过敏反应。摄入过多的异甜菊醇可能导致轻微的胃肠反应，如腹胀和腹泻。最后更新：2024-04-09 21:01:54