去甲槟榔次碱盐酸盐,英文名:Guvacine Hydrochloride,CAS:6027-91-4,化学式:C6H10ClNO2,分子量:163.6021,熔点:316 °C (decomp),MS_信息_文库

去甲槟榔次碱盐酸盐,英文名:Guvacine Hydrochloride,CAS:6027-91-4,化学式:C6H10ClNO2,分子量:163.6021,熔点:316 °C (decomp),MS

2024-11-07 0

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6027-91-4

去甲槟榔次碱盐酸盐(Guvacine Hydrochloride)

CAS: 6027-91-4

化学式: C6H10ClNO2

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中文名	去甲槟榔次碱盐酸盐
英文名	Guvacine Hydrochloride
别名	去甲槟榔次碱盐酸盐
英文别名	1,2,5,6-Tetrahydro- Guvacine Hydrochloride GUVACINE HYDROCHLORIDE 1,2,5,6-Tetrahydro-3-pyridinecarboxylic Acid Hydrochloride 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-, hydrochloride
CAS	6027-91-4
化学式	C6H10ClNO2
分子量	163.6021
熔点	316 °C (decomp)
溶解度	H2O: 可溶
存储条件	Inert atmosphere,Room Temperature
外观	固体
颜色	white
物化性质	可溶于甲醇、乙醇、DMSO等有机溶剂，来源于棕榈科植物槟榔Areca catechu L.种子。
MDL号	MFCD00055191
体外研究	Guvacine hydrochloride is a potent inhibitor of GABA transporter, dispalys modest selectivity forcloned GABA transporters with IC 50 s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3). Guvacine has low affinity at hBGT-1 (IC 50 >1 mM). Guvacine hydrochloride is a potent inhibitor of GABA uptake, but does not inhibit sodium-independent GABA binding, and is weak or inactive as a GABA receptor agonist. Guvacine inhibits the uptake GABA and β-alanine with IC 50 s of 23 ± 2 μM, 66 ± 11 μM in the Cat spinal cord, and 8 ± 1 μM, 123 ± 28 μM in the rat cerebral cortex, respectively.
危险品标志	Xi - 刺激性物品
风险术语	36/37/38 - 刺激眼睛、呼吸系统和皮肤。
安全术语	S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。
WGK Germany	3
Hazard Class	IRRITANT

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