620112-78-9
CCG-63802(CCG-63802)
CAS: 620112-78-9
化学式: C26H18N4O2S
<"" ="xl" "">中文名 | CCG-63802 |
英文名 | CCG-63802 |
别名 | 化合物 T14897 RGS抑制剂(CCG-63802) ALPHA-[[9-甲基-2-(3-甲基苯氧基)-4-氧代-4H-吡啶并[1,2-A]嘧啶-3-基]亚甲基]-2-苯并噻唑乙腈 |
英文别名 | CCG63802 CCG-63802 CCG 63802 (E)-2-(Benzo[d]thiazol-2-yl)-3-(9-methyl-4-oxo-2-(m-tolyloxy)-4H-pyrido[1,2-a]pyrimidin-3-yl)a (E)-2-(Benzo[d]thiazol-2-yl)-3-(9-methyl-4-oxo-2-(m-tolyloxy)-4H-pyrido[1,2-a]pyrimidin-3-yl)acry α-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile 2-Benzothiazoleacetonitrile, α-[[9-methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]- alpha-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile (2E)-2-(1,3-Benzothiazol-2-yl)-3-[9-methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]acrylonitrile |
CAS | 620112-78-9 |
化学式 | C26H18N4O2S |
分子量 | 450.51 |
密度 | 1.31 |
沸点 | 547.9±60.0 °C(Predicted) |
酸度系数 | -0.42±0.70(Predicted) |
存储条件 | Sealed in dry,Store in freezer, under -20°C |
体外研究 | CCG-63802 (5 μM) inhibits regulators of G-protein signaling (RGS) proteins in the presence of BK (bradykinin) and 8-Br-cGMP (membrane-permeable analogue of cGMP), HEK-293 cells start to depolarize again. |
体内研究 | CCG-63802 (0.05 mg/kg; intratracheal administration; once per week; 90 days) reduces RGS4 protein expression, leading to partially abrogate the attenuating effect of PGZ on airway inflammation, hyperresponsiveness (AHR), and remodeling. Animal Model: Forty female BALB/c mice aged 6-8 week old Dosage: 0.05 mg/kg Administration: Intratracheal administration; once per week; 90 days Result: CCG 63802 treatment in OVA +PGZ + CCG group significantly reduced RGS4 protein expression compared to OVA + PGZ group (P < 0.05) |
危险品标志 | T - 有毒物品 |
风险术语 | 25 - 吞食有毒。 |
安全术语 | 45 - 若发生事故或感不适,立即就医(可能的话,出示其标签)。 |
620112-78-9 - 配置溶液浓度参考
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.22 ml | 11.098 ml | 22.197 ml |
5 mM | 0.444 ml | 2.22 ml | 4.439 ml |
10 mM | 0.222 ml | 1.11 ml | 2.22 ml |
5 mM | 0.044 ml | 0.222 ml | 0.444 ml |