Bifemelane HCl,英文名:Bifemelane HCl,CAS:62232-46-6,化学式:C18H23NO.ClH,分子量:305.847,熔点:117-121°,MSDS.

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62232-46-6 询问

Bifemelane HCl(Bifemelane HCl)

CAS: 62232-46-6

化学式: C18H23NO.ClH

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中文名	Bifemelane HCl
英文名	Bifemelane HCl
别名	盐酸双芬麦兰 4-(2-苄基苯氧基)-N-甲基丁-1-胺盐酸盐 化合物BIFEMELANE HYDROCHLORIDE
英文别名	Bifemelane HCl Bifemelan hydrochloride Bifemelane hydrochloride MEAHDXWXNNDSAK-UHFFFAOYSA-N 4-(2-Benzylphenoxy)-N-methylbutan-1-amine hydrochloride
CAS	62232-46-6
化学式	C18H23NO.ClH
分子量	305.847
熔点	117-121°
溶解度	溶于DMSO
存储条件	-20℃
靶点	MAO inhibitor
体外研究	Bifemelane inhibits MAO-A in a dose-dependent manner, with K i s of 4.2±0.2 and 14.1±0.7 μM in human brain synaptosomes and human liver mitochondria respectively. Bifemelane inhibits MAO-B activities in a dose-dependent manner, with K i s of 46.0±3.6 and 65.2±7.0 μM in human brain synaptosomes and human liver mitochondria respectively.
上游原料	盐酸
参考资料 展开查看	1: Yoshida Y, Kumagai H, Ohkubo Y, Tsuchiya R, Morita M, Miyakawa H, Kudo Y. Effects of bifemelane on the calcium level and ATP release of the human origin astrocyte clonal cell. J Pharmacol Sci. 2006 Sep;102(1):121-8. PubMed PMID: 16974067. 2: Yoshida Y, Nakane A, Morita M, Kudo Y. A novel effect of bifemelane, a nootropic drug, on intracellular Ca2+ levels in rat cerebral astrocytes. J Pharmacol Sci. 2006 Feb;100(2):126-32. PubMed PMID: 16474207. 3: Miyazaki I, Iwata-Ichikawa E, Asanuma M, Iida M, Ogawa N. Bifemelane hydrochloride protects against cytotoxicity of hydrogen peroxide on cultured rat neuroblastoma cell line. Neurochem Res. Jul;24(7):857-60. PubMed PMID: 10403625. 4: Kinoshita M, Kaneko S, Yasuno T, Yada N, Akaike A, Satoh M. Inhibitory effects of bifemelane on brain Ca2+ channel subtypes expressed in Xenopus oocytes. Jpn J Pharmacol. 1998 Sep;78(1):39-44. PubMed PMID: 9804060.

62232-46-6 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	3.27 ml	16.348 ml	32.696 ml
5 mM	0.654 ml	3.27 ml	6.539 ml
10 mM	0.327 ml	1.635 ml	3.27 ml
5 mM	0.065 ml	0.327 ml	0.654 ml

最后更新：2024-01-02 23:10:35