62289-81-0
N-(吡啶-3-基)噻吩-2-羧酰胺(N-pyridin-3-ylthiophene-2-carboxamide)
CAS: 62289-81-0
化学式: C10H8N2OS
<"" ="xl" "">| 中文名 | N-(吡啶-3-基)噻吩-2-羧酰胺 |
| 英文名 | N-pyridin-3-ylthiophene-2-carboxamide |
| 别名 | 化合物SW-106065 N-(吡啶-3-基)噻吩-2-羧酰胺 |
| 英文别名 | SW-106065 N-pyridin-3-ylthiophene-2-carboxamide 2-Thiophenecarboxamide, N-3-pyridinyl- |
| CAS | 62289-81-0 |
| 化学式 | C10H8N2OS |
| 分子量 | 204.25 |
| 密度 | 1.352±0.06 g/cm3(Predicted) |
| 沸点 | 270.8±15.0 °C(Predicted) |
| 酸度系数 | 12.39±0.70(Predicted) |
| 体外研究 | SW106065 (Compound 21, Cpd21) inhibits the human MPNST cell lines growth in a dose-dependent manner, and EC 50 concentrations of 439 nM and 753.6 nM for S462 and SNF96.2 cells, respectively. SW106065 remains nontoxic to normally dividing Schwann cells or mouse embryonic fibroblasts. SW106065 (Cpd21; 0.25-5 µM; 24 hours; sMPNST cells) treatment shows a decreased percentage of cells in S phase, and a corresponding increased percentage in G1/G0 and G2/M. SW106065 (Cpd21; 0.25-5 µM; 24 hours; sMPNST cells) treatment decreases the levels of cyclin A2, cyclin B1, cyclin D1, cyclin E, cdk4, and cdk6. And increases levels of cdkn1a and cdkn2a mRNA were observed in a dose-dependent manner.SW106065 (Cpd21; 0.25-5 µM; 24 hours; sMPNST cells) treatment decreases the levels of Cyclin D1 protein. SW106065 (Cpd21) treatment significant increase in the percentage of apoptotic cells. Cell Cycle Analysis Cell Line: sMPNST cells Concentration: 0.25 µM, 0.5 µM, 1 µM, 2.5 µM, and 5 µM Incubation Time: 24 hours Result: Showed a decreased percentage of cells in S phase, and a corresponding increased percentage in G1/G0 and G2/M. RT-PCR Cell Line: sMPNST cells Concentration: 0.25 µM, 0.5 µM, 1 µM, 2.5 µM, and 5 µM Incubation Time: 24 hours Result: Decreased levels of cyclin A2, cyclin B1, cyclin D1, cyclin E, cdk4, and cdk6. Increased levels of cdkn1a and cdkn2a mRNA were observed in a dose-dependent manner. Western Blot Analysis Cell Line: sMPNST cells Concentration: 0.25 µM, 0.5 µM, 1 µM, 2.5 µM, and 5 µM Incubation Time: 24 hours Result: Decreased levels of Cyclin D1 protein. |
| 体内研究 | SW106065 (Cpd21; 40 mg/kg; intraperitoneal injection; twice per day for 4 weeks) treatment can be delivered to mice in concentrations to sufficiently penetrate sMPNST tissue, and inhibit tumor development. Animal Model: NCR-nu/nu female mice (6-7 week old) injected with MPNST cells Dosage: 40 mg/kg Administration: Intraperitoneal injection; twice per day for 4 weeks Result: Reduced MPNST burden in a mouse allograft model. |
62289-81-0 - 简介
N-(吡啶-3-基)噻吩-2-羧酰胺是一种有机化合物。以下是关于它的性质、用途、制法和安全信息的介绍：性质：
N-(吡啶-3-基)噻吩-2-羧酰胺是一种白色或微黄色固体，具有独特的分子结构。它具有良好的溶解性，可溶于许多有机溶剂如乙醇、二甲基亚砜和二甲基甲酰胺。
用途：
N-(吡啶-3-基)噻吩-2-羧酰胺广泛应用于化学领域。它可用作有机合成中的原料或中间体，用于合成具有特定功能的有机化合物。其在有机电子领域具有优异的光电特性，它也常被用作有机半导体材料，如有机太阳能电池、有机发光二极管和有机场效应晶体管的构建组块。
制法：
N-(吡啶-3-基)噻吩-2-羧酰胺可以通过不同的合成途径获得，最常见的方法是噻吩环和吡啶环的缩合反应。具体而言，可以通过将3-氯噻吩和吡啶在碱性条件下反应得到目标化合物。
安全信息：
N-(吡啶-3-基)噻吩-2-羧酰胺在正常使用条件下一般是相对安全的。作为一种化学物质，它仍可能对人体健康造成一定的危害。在使用过程中应避免接触皮肤、眼睛和黏膜，并注意良好的通风条件。需要严格遵循实验室的安全操作规程。在储存和处理过程中，应注意防火防爆，并保持远离火源和氧化剂。对于这种化合物的具体安全信息：可以参考相关的安全数据表。最后更新：2024-04-10 22:29:15
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