去氢钩藤碱,英文名:corynoxeine,CAS:51014-29-0,化学式:C22H26N2O4,分子量:382.46,密度:1.25,熔点:210°C,沸点:562.7±50.0 °C(Pre

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630-94-4 询问

去氢钩藤碱(corynoxeine)

CAS: 51014-29-0;630-94-4

化学式: C22H26N2O4

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中文名	去氢钩藤碱
英文名	corynoxeine
别名	去氢钩藤碱 异去氢钩藤碱 异柯诺辛因碱 异去氢钩藤碱(标准品) 异去氢钩藤碱(对照品) 异去氢钩藤碱?, BR 异去氢钩藤碱(异柯诺辛因碱 ) ISOCORYNOXEINE 异去氢钩藤碱
英文别名	corynoxeine Isocorynoxeine Isocorynoxeine, BR Isocorynoxeine (7-Isocorynoxeine) methyl (16E,20alpha)-16-(methoxymethylidene)-2-oxocorynox-18-en-17-oate (16E,20α)-16,17,18,19-Tetradehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester methyl (E)-2-[(3S,6'R,7'S,8'aS)-6'-ethenyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethenyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,1'S,6'R,7'S,8'aS)- (alphaE,1'S,6'R,7'S,8'aS)-6'-ethenyl-1,2,2',3',6',7',8',8'a-octahydro-alpha-(methoxymethylene)-2-oxospiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid methyl ester
CAS	51014-29-0 630-94-4
化学式	C22H26N2O4
分子量	382.46
InChI	InChI=1/C22H26N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h4-8,13-15,19H,1,9-12H2,2-3H3,(H,23,26)/b16-13+/t14-,15-,19-,22-/m0/s1
密度	1.25
熔点	210°C
沸点	562.7±50.0 °C(Predicted)
比旋光度	(CHCl3)-21；(c, 1 in Py)+23
闪点	294.1°C
蒸汽压	1.09E-12mmHg at 25°C
溶解度	溶于氯仿，尚可溶于丙酮、乙醇、苯，微溶于乙醚和乙酸乙酯，不溶于石油醚。
折射率	1.605
酸度系数	13.54±0.60(Predicted)
存储条件	2-8℃
外观	浅黄色粉末
物化性质	白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于钩藤。
MDL号	MFCD20527288
体外研究	Isocorynoxeine inhibits 5-HT 2A receptor-mediated 5-HT currents. Isocorynoxeine prefer to interact with 5-HT 2A receptors rather than with 5-HT 2C receptors in the brain.Isocorynoxeine exhibits less potent inhibitory activity (with IC 50 values of > 100 μM) against the 5-HT 2C receptor-mediated response than the 5-HT 2A receptor-mediated response in oocytes. Isocorynoxeine dose-dependently and competitively inhibits 5-HT-evoked currents in Xenopus oocytes expressing 5-HT 2A receptors, but has less of a suppressive effect on those in oocytes expressing 5-HT 2C receptors.
体内研究	The effects of Rhynchophylline, Corynoxeine, and Isocorynoxeine, isorhynchophylline-related alkaloids present are tested in Uncaria species, on 5-MeO-DMT-induced head-twitch behaviour in reserpinized mice. Neither Rhynchophylline [H=1.369, P=0.504] nor Corynoxeine [H=0.242, P=0.886] affects the behaviour, while Isocorynoxeine significantly attenuates it at 30 mg/kg (i.p.) [H=7.582, P<0.01].
参考资料 展开查看	1. 郭晓敏, 黄宝媛, 曾常青. 钩藤生物碱提取物及其单体逆转HepG2/ADM细胞耐药活性的筛选[J]. 广东药学院学报, 2018, 034(004):447-451. 2. [IF=3.935] Shuanglu Xie et al."Systematic identification and quantification of tetracyclic monoterpenoid oxindole alkaloids in Uncaria rhynchophylla and their fragmentations in Q-TOF-MS spectra."J Pharmaceut Biomed. 2013 Jul;81-82:56 3. [IF=4.759] Keyu Feng et al."Configuration of the ion exchange chromatography, hydrophilic interaction chromatography, and reversed-phase chromatography as off-line three-dimensional chromatography coupled with high-resolution quadrupole-Orbitrap mass spectrometry fo 4. [IF=3.935] Wenwen Huang et al."Rapid discovery of potentially vasodilative compounds from Uncaria by UHPLC/Q-Orbitrap-MS based metabolomics and correlation analysis."J Pharmaceut Biomed. 2021 Nov;206:114384