Human DEP-1/CD148 Phycoerythrin MAb (Clone 143-41) 100 TESTS

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Human DEP-1/CD148 Phycoerythrin MAb (Clone 143-41) 100 TESTS信息二维码

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产品介绍

    基本参数

    详细说明

    • Species Reactivity

      Human

    • Specificity

      Detects human DEP-1/CD148 in Western blots.

    • Source

      Monoclonal Mouse IgG    1 Clone # 143-41

    • Purification

      Protein A or G purified from hybridoma culture supernatant

    • Immunogen

      Phytohemagglutinin-stimulated human peripheral blood mononuclear cells

    • Formulation

      Supplied in a saline solution containing BSA and Sodium Azide.

    • Label

      Phycoerythrin

    Applications

    • Recommended    
      Concentration

      Sample

    • Flow Cytometry

      10 µL/10    6 cells

      See below


    Please Note: Optimal dilutions should be determined by each laboratory for each application.  are available in the Technical Information section on our website.

    Data Examples

    Flow Cytometry      
         

    Detection of DEP‑1/CD148 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human DEP‑1/CD148 PE‑conjugated Monoclonal Antibody (Catalog # FAB1934P, filled histogram) or isotype control antibody (Catalog # , open histogram). View our protocol for .


    Preparation and Storage

    • Shipping

      The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

    • Stability & Storage

      Protect from light.    Do not freeze.    

      • 12 months from date of receipt, 2 to 8 °C as supplied.

    Background: DEP-1/CD148

    Density Enhanced Protein Tyrosine Phosphatase (DEP-1), also known as CD148, HPTP-eta, and PTP Receptor Type J (PTPRJ), is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. A large (220 kDa) glycoprotein found at the cell surface, DEP-1 levels are increased with high cell density (1). DEP-1 phosphatase activity is enhanced by basement membrane proteins (2), suggesting it is involved in regulating cell adhesion and contact interactions. High levels of expression dampen PDGF (3), VEGF (4), and T-cell receptor (5) responses. DEP-1 is widely expressed in tissues, particularly ones forming epithelioid monolayers (6). In the immune system, DEP-1 is found on all cell lineages and is highest on granulocytes (7).   Dep-1 is the mutated gene in the Susceptibility to Colon Cancer locus   Scc1, which is altered in many human colorectal adenomas (8). Gene knockout mice lacking DEP-1 die at midgestation due to failures in cardiovascular development (9). DEP-1 dephosphorylates a variety of proteins, including the HGF (10), PDGF (11), and VEGF (4) receptors, and beta-Catenin (12). The recombinant protein is the intracellular region of DEP-1 containing the catalytic domain.

    • References:

      1. Ostman, A. et al. (1994) Proc. Natl. Acad. Sci. USA 91:9680.

      2. Sorby, M. et al. (2001) Oncogene 20:5219.

      3. Jandt, E. et al. (2003) Oncogene 22:4175.

      4. Lampugnani, M.G. et al. (2003) J. Cell Biol. 161:793.

      5. Baker, J.E. et al. (2001) Mol. Cell. Biol. 21:2393.

      6. Borges, L.G. et al. (1996) Circ. Res. 79:570.

      7. de la Fuente-Garcia, M.A. et al. (1998) Blood 91:2800.

      8. Ruivenkamp, C.A. et al. (2002) Nat. Genet. 31:295.

      9. Takahashi, T. et al. (2003) Mol. Cell. Biol. 23:1817.

      10. Palka, H.L. et al. (2003) J. Biol. Chem. 278:5728.

      11. Kovalenko, M. et al. (2000) J. Biol. Chem. 275:16219.

      12. Holsinger, L.J. et al. (2002) Oncogene 21:7067.

    • Long Name:

      Density Enhanced Receptor Protein Tyrosine Phosphatase

    • Entrez Gene IDs:

      5795 (Human); 19271 (Mouse); 29645 (Rat)

    • Alternate Names:

      CD148 antigen; CD148; Density-enhanced phosphatase 1; DEP1; DEP-1; DEP1EC 3.1.3.48; HPTP eta; HPTPeta; HPTP-eta; human density enhanced phosphatase-1; protein tyrosine phosphatase, receptor type, J polypeptide; protein tyrosine phosphatase, receptor type, J; Protein-tyrosine phosphatase eta; Protein-tyrosine phosphatase receptor type J; PTPRJ; receptor-type tyrosine-protein phosphatase eta; R-PTP-ETA; R-PTP-J; SCC1; susceptibility to colon cancer 1, mouse, homolog of








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