Human Epiregulin MAb (Clone 183629) 100 UG

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Human Epiregulin MAb (Clone 183629) 100 UG信息二维码

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产品介绍

    基本参数

    详细说明

    • Species Reactivity

      Human

    • Specificity

      Detects human Epiregulin in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) Betacellulin, rhEGF, recombinant mouse Epiregulin, or rhHB-EGF is observed.

    • Source

      Monoclonal Mouse IgG    2B Clone # 183629

    • Purification

      Protein A or G purified from hybridoma culture supernatant

    • Immunogen

      E. coli-derived recombinant human Epiregulin    
      Val63-Leu108    
      Accession # O14944

    • Formulation

      Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

    • Label

      Unconjugated

    Applications

    • Recommended    
      Concentration

      Sample

    • CyTOF-ready

      Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.


    • Intracellular Staining by Flow Cytometry

      2.5 µg/10    6 cells

      A549 human lung carcinoma cell line fixed with paraformaldehyde and permeabilized with saponin


    Please Note: Optimal dilutions should be determined by each laboratory for each application.  are available in the Technical Information section on our website.

    Preparation and Storage

    • Reconstitution

      Reconstitute at 0.5 mg/mL in sterile PBS.

    • Shipping

      The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

    • Stability & Storage

      Use a manual defrost freezer and avoid repeated freeze-thaw cycles.    

      • 12 months from date of receipt, -20 to -70 °C as supplied.

      • 1 month, 2 to 8 °C under sterile conditions after reconstitution.

      • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

    Background: Epiregulin

    Epiregulin is a member of the EGF family of growth factors which includes, among others, epidermal growth factor (EGF), transforming growth factor (TGF)-alpha, amphiregulin (ARG), HB (heparin-binding)-EGF, betacellulin, and the various heregulins. All EGF family members are synthesized as transmembrane precursors and are converted to soluble forms by proteolytic cleavage. Epiregulin was originally purified from the mouse fibroblast-derived tumor cell line NIH3T3/T7 (1). The human epiregulin cDNA encodes a 169 amino acid (aa) residues transmembrane precursor with a 29 aa signal peptide, a 21 aa transmembrane domain and a 21 aa cytoplasmic domain. The putative soluble mature Epiregulin comprising the EGF-like domain (aa residues 64‑104) is formed by proteolytic removal of the propeptide regions (2). There is 85% aa sequence homology between human and mouse epiregulins. Epiregulin is expressed primarily in the placenta and macrophages (3). High level expression has also been detected in various carcinomas. Epiregulin specifically binds EGFR (ErbB1) and ErbB4 but not ErbB2 and ErbB3. It activates the homodimers of both ErbB1 and ErbB4. In addition, epiregulin can also activate all possible heteromeric combinations of the four ErbB family members (4). Epiregulin stimulates the proliferation of fibroblasts, smooth muscle cells and hepatocytes. It has been shown to be an autocrine growth factor for epidermal keratinocytes as well as mesangial cells (5, 6). Epiregulin has also been shown to inhibit growth of several epithelial tumor cells. In addition, Epiregulin has been implicated in the implantation process during pregnancy (7).

    • References:

      1. Toyoda, H. et al. (1995) J. Biol. Chem. 270:7495.

      2. Toyoda, H. et al. (1997) Biochem. J. 326:69.

      3. Komurasaki, T. et al. (1997) Oncogene 15:2841.

      4. Shelly, M. et al. (1998) J. Biol. Chem. 273:10496.

      5. Shirakata, Y. et al. (2000) J. Biol. Chem. 275:5748.

      6. Mishre, R. et al. (2002) Am. J. Physiol. Renal. Physiol. 283:F1151.

      7. Das, S.K. et al. (1997) Dev. Biol. 190:178.

    • Entrez Gene IDs:

      2069 (Human); 13874 (Mouse)

    • Alternate Names:

      Epiregulin; ER; EREG; proepiregulin



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